Seroatlas · Human Serome Atlas

DBNL

Drebrin-like protein

Also known as: ABP1, DBNL_HUMAN, HIP-55, SH3P7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UJU6
Gene
DBNL
Ensembl
ENSG00000136279
Chromosome
7
Canonical length
430 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane

OverviewNCBI Gene

Enables cadherin binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; nervous system development; and podosome assembly. Located in cytoplasm; intracellular membrane-bounded organelle; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

430 residues, UniProt reviewed canonical sequence.

>Q9UJU6|DBNL
     1  MAANLSRNGP ALQEAYVRVV TEKSPTDWAL FTYEGNSNDI RVAGTGEGGL EEMVEELNSG
    61  KVMYAFCRVK DPNSGLPKFV LINWTGEGVN DVRKGACASH VSTMASFLKG AHVTINARAE
   121  EDVEPECIME KVAKASGANY SFHKESGRFQ DVGPQAPVGS VYQKTNAVSE IKRVGKDSFW
   181  AKAEKEEENR RLEEKRRAEE AQRQLEQERR ERELREAARR EQRYQEQGGE ASPQRTWEQQ
   241  QEVVSRNRNE QESAVHPREI FKQKERAMST TSISSPQPGK LRSPFLQKQL TQPETHFGRE
   301  PAAAISRPRA DLPAEEPAPS TPPCLVQAEE EAVYEEPPEQ ETFYEQPPLV QQQGAGSEHI
   361  DHHIQGQGLS GQGLCARALY DYQAADDTEI SFDPENLITG IEVIDEGWWR GYGPDGHFGM
   421  FPANYVELIE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DBNL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
166 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 166 nTPM
  • spleen: 108 nTPM
  • lymph node: 93 nTPM
  • tonsil: 84 nTPM
  • vagina: 78 nTPM
  • bone marrow: 72 nTPM

Single-cell type

  • esophageal apical cells: 951 nCPM
  • platelets: 371 nCPM
  • esophageal suprabasal cells: 367 nCPM
  • megakaryocytes: 315 nCPM
  • hofbauer cells: 223 nCPM
  • extravillous trophoblasts: 199 nCPM

Immune cell

  • total PBMC: 558 nTPM
  • non-classical monocyte: 440 nTPM
  • intermediate monocyte: 423 nTPM
  • classical monocyte: 377 nTPM
  • plasmacytoid DC: 377 nTPM
  • myeloid DC: 363 nTPM

Brain region

  • pons: 53 nTPM
  • medulla oblongata: 47 nTPM
  • cerebral cortex: 46 nTPM
  • hypothalamus: 46 nTPM
  • midbrain: 45 nTPM
  • hippocampal formation: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.02
gnomAD missense Z
1.11
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DBNL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DBNL as an antibody target. Whether an autoantibody or antibody against DBNL could matter depends on whether native DBNL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DBNL is annotated at the cell surface, where native DBNL is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DBNL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DBNL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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