WH1 domain

Definition

WASp Homology domain 1 (WH1) domain. WASP is the protein that is defective in Wiskott-Aldrich syndrome (WAS). The majority of point mutations occur within the amino- terminal WH1 domain. The metabotropic glutamate receptors mGluR1alpha and mGluR5 bind a protein called homer, which is a WH1 domain homologue PMID:9428607. A subset of WH1 domains has been termed a "EVH1" domain PMID:9312002 and appear to bind a polyproline motif.

11 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (11 proteins: gene, accession, name)

• ENAH
• EVL
• HOMER1
• HOMER2
• HOMER3
• SPRED1
• SPRED2
• SPRED3
• VASP
• WAS
• WASL