Seroatlas · Human Serome Atlas

WIPF2

WAS/WASL-interacting protein family member 2

Also known as: WICH, WIPF2_HUMAN, WIRE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TF74
Gene: WIPF2
Ensembl: ENSG00000171475
Chromosome: 17
Canonical length: 440 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

440 residues, UniProt reviewed canonical sequence.

>Q8TF74|WIPF2
     1  MPIPPPPPPP PGPPPPPTFH QANTEQPKLS RDEQRGRGAL LQDICKGTKL KKVTNINDRS
    61  APILEKPKGS SGGYGSGGAA LQPKGGLFQG GVLKLRPVGA KDGSENLAGK PALQIPSSRA
   121  AAPRPPVSAA SGRPQDDTDS SRASLPELPR MQRPSLPDLS RPNTTSSTGM KHSSSAPPPP
   181  PPGRRANAPP TPLPMHSSKA PAYNREKPLP PTPGQRLHPG REGPPAPPPV KPPPSPVNIR
   241  TGPSGQSLAP PPPPYRQPPG VPNGPSSPTN ESAPELPQRH NSLHRKTPGP VRGLAPPPPT
   301  SASPSLLSNR PPPPARDPPS RGAAPPPPPP VIRNGARDAP PPPPPYRMHG SEPPSRGKPP
   361  PPPSRTPAGP PPPPPPPLRN GHRDSITTVR SFLDDFESKY SFHPVEDFPA PEEYKHFQRI
   421  YPSKTNRAAR GAPPLPPILR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WIPF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 19 nTPM
bone marrow: 16 nTPM
skin: 15 nTPM
basal ganglia: 14 nTPM
esophagus: 14 nTPM
amygdala: 14 nTPM

Single-cell type

neutrophils: 392 nCPM
bergmann glia: 274 nCPM
neutrophil progenitors: 187 nCPM
urothelial cells: 146 nCPM
esophageal apical cells: 144 nCPM
astrocytes: 142 nCPM

Immune cell

neutrophil: 7.1 nTPM
basophil: 5.1 nTPM
gdT-cell: 3.3 nTPM
memory B-cell: 2.9 nTPM
MAIT T-cell: 2.7 nTPM
NK-cell: 2.6 nTPM

Brain region

cerebral cortex: 87 nTPM
thalamus: 59 nTPM
hypothalamus: 59 nTPM
amygdala: 56 nTPM
cerebellum: 55 nTPM
basal ganglia: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0.19
gnomAD missense Z: 0.16
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

actin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WIPF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WIPF2 as an antibody target. Whether an autoantibody or antibody against WIPF2 could matter depends on whether native WIPF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WIPF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WIPF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...