Seroatlas · Human Serome Atlas

WIPF3

WAS/WASL-interacting protein family member 3

Also known as: CR16, FLJ36931, WIPF3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NGB9
Gene
WIPF3
Ensembl
ENSG00000122574
Chromosome
7
Canonical length
483 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Predicted to enable alpha-tubulin binding activity and gamma-tubulin binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation; endosomal transport; and exocytosis. Predicted to be located in cytosol. Predicted to be part of WASH complex. Predicted to be active in early endosome; recycling endosome; and synapse. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

483 residues, UniProt reviewed canonical sequence.

>A6NGB9|WIPF3
     1  MPVPPPPPPP LPPPPPPLGA PPPPPPSAPP VSTDTSSLRR ADPKGRSALL ADIQQGTRLR
    61  KVTQINDRSA PQIESSKGTN KEGGGSANTR GASTPPTLGD LFAGGFPVLR PAGQRDVAGG
   121  KTGQGPGSRA PSPRLPNKTI SGPLIPPASP RLGNTSEAHG AARTAPPRPN VPAPPPPTPP
   181  PPPPPLPPPL PSSSPIKTPL VSPPGPLTKG NLPVVAPPVP CAPPPPPPPP PPTPPPLPPA
   241  SVLSDKAVKP QLAPLHLPPI PPPLPLLPPC GYPGLKAEPA SPAQDAQEPP APPPPLPPYA
   301  SCSPRASLPA PPLPGVNSSS ETPPPLPPKS PSFQAPPQKA GAQALPAPPA PPGSQPFLQK
   361  KRHGRPGAGG GKLNPPPAPP ARSPTTELSS KSQQATAWTP TQQPGGQLRN GSLHIIDDFE
   421  SKFTFHSVED FPPPDEYKPC QKIYPSKIPR SRTPGPWLQA EAVGQSSDDI KGRNSQLSLK
   481  TLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WIPF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.73
Highest tissue expression
57 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 57 nTPM
  • hippocampal formation: 37 nTPM
  • basal ganglia: 29 nTPM
  • skeletal muscle: 29 nTPM
  • testis: 23 nTPM
  • epididymis: 18 nTPM

Single-cell type

  • granulosa cells: 598 nCPM
  • podocytes: 528 nCPM
  • sertoli cells: 492 nCPM
  • myonuclei: 321 nCPM
  • peritubular myoid cells: 186 nCPM
  • ovarian stromal cells: 121 nCPM

Immune cell

  • basophil: 0.6 nTPM
  • plasmacytoid DC: 0.3 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • non-classical monocyte: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • intermediate monocyte: 0.1 nTPM

Brain region

  • cerebral cortex: 115 nTPM
  • hippocampal formation: 97 nTPM
  • basal ganglia: 59 nTPM
  • amygdala: 31 nTPM
  • white matter: 29 nTPM
  • thalamus: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WIPF3.

Disease | ImmuneIEDB

Conditions an epitope on WIPF3 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.81
gnomAD pLI
0
gnomAD missense Z
-0.33
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WIPF3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WIPF3 as an antibody target. Whether an autoantibody or antibody against WIPF3 could matter depends on whether native WIPF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WIPF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WIPF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WIPF3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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