Seroatlas · Human Serome Atlas

STX1B

Syntaxin-1B

Also known as: STX1B_HUMAN, STX1B1, STX1B2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P61266
Gene
STX1B
Ensembl
ENSG00000099365
Chromosome
16
Canonical length
288 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nuclear membrane,Vesicles

OverviewNCBI Gene

The protein encoded by this gene belongs to a family of proteins thought to play a role in the exocytosis of synaptic vesicles. Vesicle exocytosis releases vesicular contents and is important to various cellular functions. For instance, the secretion of transmitters from neurons plays an important role in synaptic transmission. After exocytosis, the membrane and proteins from the vesicle are retrieved from the plasma membrane through the process of endocytosis. Mutations in this gene have been identified as one cause of fever-associated epilepsy syndromes. A possible link between this gene and Parkinson's disease has also been suggested. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>P61266|STX1B
     1  MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV EQVKKQHSAI
    61  LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE QEEGLNRSSA DLRIRKTQHS
   121  TLSRKFVEVM TEYNATQSKY RDRCKDRIQR QLEITGRTTT NEELEDMLES GKLAIFTDDI
   181  KMDSQMTKQA LNEIETRHNE IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV
   241  DYVERAVSDT KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STX1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
141 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 141 nTPM
  • cerebral cortex: 102 nTPM
  • basal ganglia: 52 nTPM
  • amygdala: 46 nTPM
  • hippocampal formation: 46 nTPM
  • hypothalamus: 43 nTPM

Single-cell type

  • retinal amacrine cells: 71 nCPM
  • brain excitatory neurons: 61 nCPM
  • brain inhibitory neurons: 48 nCPM
  • other brain neurons: 38 nCPM
  • retinal horizontal cells: 34 nCPM
  • epicardial cells: 27 nCPM

Immune cell

  • memory CD4 T-cell: 0.2 nTPM
  • basophil: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • cerebral cortex: 433 nTPM
  • pons: 260 nTPM
  • white matter: 256 nTPM
  • cerebellum: 189 nTPM
  • medulla oblongata: 183 nTPM
  • hippocampal formation: 152 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STX1B.

Disease | AllUniProt

Conditions STX1B is implicated in, by any mechanism.

  • Generalized epilepsy with febrile seizures plus 9 (GEFSP9) MIM:616172

Disease | GeneticClinVar

70 pathogenic / likely-pathogenic of 444 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
0.99
gnomAD missense Z
2.94
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STX1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STX1B as an antibody target. Whether an autoantibody or antibody against STX1B could matter depends on whether native STX1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STX1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STX1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STX1B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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