Seroatlas · Human Serome Atlas

RHNO1

RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

Also known as: C12orf32, HKMT1188, MGC13204, RHINO, RHNO1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BSD3
Gene: RHNO1
Ensembl: ENSG00000171792
Chromosome: 12
Canonical length: 238 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables chromatin-protein adaptor activity. Involved in several processes, including DNA repair; cellular response to radiation; and regulation of cell cycle process. Located in chromosome and nucleus. Is active in chromatin and site of double-strand break. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

238 residues, UniProt reviewed canonical sequence.

>Q9BSD3|RHNO1
     1  MPPRKKRRQP SQKAPLLFHQ QPLEGPKHSC ASTQLPITHT RQVPSKPIDH STITSWVSPD
    61  FDTAAGSLFP AYQKHQNRAR HSSRKPTTSK FPHLTFESPQ SSSSETLGIP LIRECPSESE
   121  KDVSRRPLVP VLSPQSCGNM SVQALQSLPY VFIPPDIQTP ESSSVKEELI PQDQKENSLL
   181  SCTLHTGTPN SPEPGPVLVK DTPEDKYGIK VTWRRRQHLL AYLRERGKLS RSQFLVKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHNO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

thymus: 24 nTPM
epididymis: 21 nTPM
tonsil: 20 nTPM
lymph node: 18 nTPM
bone marrow: 16 nTPM
esophagus: 16 nTPM

Single-cell type

paneth cells: 3.9 nCPM
epididymal principal cells: 2.5 nCPM
erythrocyte progenitors: 1.9 nCPM
monocyte progenitors: 1.8 nCPM
plasma cells: 1.7 nCPM
thymocytes: 1.7 nCPM

Immune cell

T-reg: 55 nTPM
naive B-cell: 42 nTPM
naive CD4 T-cell: 37 nTPM
memory CD4 T-cell: 36 nTPM
eosinophil: 35 nTPM
memory CD8 T-cell: 32 nTPM

Brain region

white matter: 31 nTPM
cerebral cortex: 26 nTPM
hypothalamus: 25 nTPM
hippocampal formation: 24 nTPM
pons: 24 nTPM
amygdala: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 0.02
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

chromatin-protein adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Rad9, Rad1, Hus1-interacting nuclear orphan protein 1
RAD9, RAD1, HUS1-interacting nuclear orphan protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RHNO1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHNO1 as an antibody target. Whether an autoantibody or antibody against RHNO1 could matter depends on whether native RHNO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHNO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RHNO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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