Seroatlas · Human Serome Atlas

ZNRF2

E3 ubiquitin-protein ligase ZNRF2

Also known as: RNF202, ZNRF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NHG8
Gene: ZNRF2
Ensembl: ENSG00000180233
Chromosome: 7
Canonical length: 242 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Vesicles

OverviewNCBI Gene

Enables ubiquitin protein ligase activity. Involved in positive regulation of autophagosome-lysosome fusion. Located in cytoplasmic vesicle membrane; nuclear lumen; and plasma membrane. Part of protein-containing complex. Is active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

242 residues, UniProt reviewed canonical sequence.

>Q8NHG8|ZNRF2
     1  MGAKQSGPAA ANGRTRAYSG SDLPSSSSGG ANGTAGGGGG ARAAAAGRFP AQVPSAHQPS
    61  ASGGAAAAAA APAAPAAPRS RSLGGAVGSV ASGARAAQSP FSIPNSSSGP YGSQDSVHSS
   121  PEDGGGGRDR PVGGSPGGPR LVIGSLPAHL SPHMFGGFKC PVCSKFVSSD EMDLHLVMCL
   181  TKPRITYNED VLSKDAGECA ICLEELQQGD TIARLPCLCI YHKGCIDEWF EVNRSCPEHP
   241  SD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNRF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

testis: 23 nTPM
kidney: 21 nTPM
liver: 20 nTPM
colon: 18 nTPM
rectum: 15 nTPM
small intestine: 14 nTPM

Single-cell type

microglia: 410 nCPM
pituicytes/fscs: 300 nCPM
cone photoreceptor cells: 228 nCPM
endometrial luminal cells: 215 nCPM
pdcs: 209 nCPM
endometrial ciliated cells: 206 nCPM

Immune cell

plasmacytoid DC: 2.3 nTPM
T-reg: 1 nTPM
eosinophil: 0.5 nTPM
MAIT T-cell: 0.5 nTPM
memory B-cell: 0.5 nTPM
memory CD8 T-cell: 0.5 nTPM

Brain region

choroid plexus: 46 nTPM
medulla oblongata: 33 nTPM
thalamus: 33 nTPM
white matter: 32 nTPM
spinal cord: 32 nTPM
midbrain: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0.07
gnomAD missense Z: 1.07
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNRF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNRF2 as an antibody target. Whether an autoantibody or antibody against ZNRF2 could matter depends on whether native ZNRF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNRF2 is annotated at the cell surface, where native ZNRF2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ZNRF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...