Seroatlas · Human Serome Atlas

GPS2

G protein pathway suppressor 2

Also known as: GPS2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13227
Gene: GPS2
Ensembl: ENSG00000132522
Chromosome: 17
Canonical length: 327 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>Q13227|GPS2
     1  MPALLERPKL SNAMARALHR HIMMERERKR QEEEEVDKMM EQKMKEEQER RKKKEMEERM
    61  SLEETKEQIL KLEEKLLALQ EEKHQLFLQL KKVLHEEEKR RRKEQSDLTT LTSAAYQQSL
   121  TVHTGTHLLS MQGSPGGHNR PGTLMAADRA KQMFGPQVLT TRHYVGSAAA FAGTPEHGQF
   181  QGSPGGAYGT AQPPPHYGPT QPAYSPSQQL RAPSAFPAVQ YLSQPQPQPY AVHGHFQPTQ
   241  TGFLQPGGAL SLQKQMEHAN QQTGFSDSSS LRPMHPQALH PAPGLLASPQ LPVQMQPAGK
   301  SGFAATSQPG PRLPFIQHSQ NPRFYHK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 174 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 174 nTPM
testis: 120 nTPM
heart muscle: 77 nTPM
blood vessel: 73 nTPM
kidney: 66 nTPM
adrenal gland: 62 nTPM

Single-cell type

oligodendrocytes: 43 nCPM
bergmann glia: 42 nCPM
brain excitatory neurons: 40 nCPM
microglia: 39 nCPM
astrocytes: 36 nCPM
brain inhibitory neurons: 34 nCPM

Immune cell

eosinophil: 83 nTPM
memory B-cell: 82 nTPM
T-reg: 81 nTPM
neutrophil: 79 nTPM
basophil: 79 nTPM
non-classical monocyte: 68 nTPM

Brain region

cerebral cortex: 28 nTPM
medulla oblongata: 21 nTPM
white matter: 20 nTPM
pons: 20 nTPM
thalamus: 20 nTPM
hypothalamus: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GPS2.

Disease | ImmuneIEDB

Conditions an epitope on GPS2 was assayed in.

skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.05
gnomAD missense Z: 1.16
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

G protein pathway suppressor 2
G-protein pathway suppressor

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPS2 as an antibody target. Whether an autoantibody or antibody against GPS2 could matter depends on whether native GPS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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