Seroatlas · Human Serome Atlas

UBE2V1

Ubiquitin-conjugating enzyme E2 variant 1

Also known as: CROC-1, CROC1, UB2V1_HUMAN, UBE2V, UEV-1, UEV1A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13404
Gene
UBE2V1
Ensembl
ENSG00000244687
Chromosome
20
Canonical length
147 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

147 residues, UniProt reviewed canonical sequence.

>Q13404|UBE2V1
     1  MAATTGSGVK VPRNFRLLEE LEEGQKGVGD GTVSWGLEDD EDMTLTRWTG MIIGPPRTIY
    61  ENRIYSLKIE CGPKYPEAPP FVRFVTKINM NGVNSSNGVV DPRAISVLAK WQNSYSIKVV
   121  LQELRRLMMS KENMKLPQPP EGQCYSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2V1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
84 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 84 nTPM
  • skeletal muscle: 82 nTPM
  • cerebral cortex: 77 nTPM
  • choroid plexus: 75 nTPM
  • liver: 73 nTPM
  • esophagus: 69 nTPM

Single-cell type

  • other brain neurons: 64 nCPM
  • brain excitatory neurons: 63 nCPM
  • esophageal apical cells: 57 nCPM
  • microglia: 57 nCPM
  • brain inhibitory neurons: 55 nCPM
  • platelets: 55 nCPM

Immune cell

  • total PBMC: 351 nTPM
  • NK-cell: 234 nTPM
  • MAIT T-cell: 222 nTPM
  • gdT-cell: 220 nTPM
  • memory CD8 T-cell: 211 nTPM
  • naive CD8 T-cell: 198 nTPM

Brain region

  • cerebral cortex: 127 nTPM
  • basal ganglia: 95 nTPM
  • hippocampal formation: 88 nTPM
  • amygdala: 84 nTPM
  • thalamus: 84 nTPM
  • white matter: 83 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.37
gnomAD pLI
0
gnomAD missense Z
1.55
DepMap mean gene effect
-0.31
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2V1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2V1 as an antibody target. Whether an autoantibody or antibody against UBE2V1 could matter depends on whether native UBE2V1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2V1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2V1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBE2V1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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