Seroatlas · Human Serome Atlas

DLGAP5

Disks large-associated protein 5

Also known as: DLG1, DLG7, DLGP5_HUMAN, HURP, KIAA0008

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15398
Gene: DLGAP5
Ensembl: ENSG00000126787
Chromosome: 14
Canonical length: 846 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Mitotic spindle,Cytosol

OverviewNCBI Gene

Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centrosome localization; kinetochore assembly; and mitotic spindle organization. Located in cytosol; nucleus; and spindle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

846 residues, UniProt reviewed canonical sequence.

>Q15398|DLGAP5
     1  MSSSHFASRH RKDISTEMIR TKIAHRKSLS QKENRHKEYE RNRHFGLKDV NIPTLEGRIL
    61  VELDETSQGL VPEKTNVKPR AMKTILGDQR KQMLQKYKEE KQLQKLKEQR EKAKRGIFKV
   121  GRYRPDMPCF LLSNQNAVKA EPKKAIPSSV RITRSKAKDQ MEQTKIDNES DVRAIRPGPR
   181  QTSEKKVSDK EKKVVQPVMP TSLRMTRSAT QAAKQVPRTV SSTTARKPVT RAANENEPEG
   241  KVPSKGRPAK NVETKPDKGI SCKVDSEENT LNSQTNATSG MNPDGVLSKM ENLPEINTAK
   301  IKGKNSFAPK DFMFQPLDGL KTYQVTPMTP RSANAFLTPS YTWTPLKTEV DESQATKEIL
   361  AQKCKTYSTK TIQQDSNKLP CPLGPLTVWH EEHVLNKNEA TTKNLNGLPI KEVPSLERNE
   421  GRIAQPHHGV PYFRNILQSE TEKLTSHCFE WDRKLELDIP DDAKDLIRTA VGQTRLLMKE
   481  RFKQFEGLVD DCEYKRGIKE TTCTDLDGFW DMVSFQIEDV IHKFNNLIKL EESGWQVNNN
   541  MNHNMNKNVF RKKVVSGIAS KPKQDDAGRI AARNRLAAIK NAMRERIRQE ECAETAVSVI
   601  PKEVDKIVFD AGFFRVESPV KLFSGLSVSS EGPSQRLGTP KSVNKAVSQS RNEMGIPQQT
   661  TSPENAGPQN TKSEHVKKTL FLSIPESRSS IEDAQCPGLP DLIEENHVVN KTDLKVDCLS
   721  SERMSLPLLA GGVADDINTN KKEGISDVVE GMELNSSITS QDVLMSSPEK NTASQNSILE
   781  EGETKISQSE LFDNKSLTTE CHLLDSPGLN CSNPFTQLER RHQEHARHIS FGGNLITFSP
   841  LQPGEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DLGAP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

thymus: 39 nTPM
bone marrow: 28 nTPM
tonsil: 18 nTPM
lymph node: 17 nTPM
testis: 16 nTPM
appendix: 7.7 nTPM

Single-cell type

oocytes: 281 nCPM
erythrocyte progenitors: 233 nCPM
monocyte progenitors: 162 nCPM
megakaryocyte progenitors: 81 nCPM
late primary spermatocytes: 72 nCPM
neutrophil progenitors: 63 nCPM

Immune cell

T-reg: 5.4 nTPM
memory CD4 T-cell: 1.9 nTPM
memory CD8 T-cell: 1.4 nTPM
NK-cell: 1 nTPM
total PBMC: 0.7 nTPM
memory B-cell: 0.6 nTPM

Brain region

white matter: 7.5 nTPM
cerebral cortex: 4.2 nTPM
hypothalamus: 3.9 nTPM
amygdala: 3.3 nTPM
hippocampal formation: 2.8 nTPM
thalamus: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DLGAP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DLGAP5 as an antibody target. Whether an autoantibody or antibody against DLGAP5 could matter depends on whether native DLGAP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DLGAP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DLGAP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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