Seroatlas · Human Serome Atlas

TCP11L2

T-complex protein 11-like protein 2

Also known as: MGC40368, T11L2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N4U5
Gene
TCP11L2
Ensembl
ENSG00000166046
Chromosome
12
Canonical length
519 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

Predicted to be involved in muscle cell migration and signal transduction. Predicted to be located in cytoskeleton. Predicted to be part of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

519 residues, UniProt reviewed canonical sequence.

>Q8N4U5|TCP11L2
     1  MPFNGEKQCV GEDQPSDSDS SRFSESMASL SDYECSRQSF ASDSSSKSSS PASTSPPRVV
    61  TFDEVMATAR NLSNLTLAHE IAVNENFQLK QEALPEKSLA GRVKHIVHQA FWDVLDSELN
   121  ADPPEFEHAI KLFEEIREIL LSFLTPGGNR LRNQICEVLD TDLIRQQAEH SAVDIQGLAN
   181  YVISTMGKLC APVRDNDIRE LKATGNIVEV LRQIFHVLDL MQMDMANFTI MSLRPHLQRQ
   241  LVEYERTKFQ EILEETPSAL DQTTEWIKES VNEELFSLSE SALTPGAENT SKPSLSPTLV
   301  LNNSYLKLLQ WDYQKKELPE TLMTDGARLQ ELTEKLNQLK IIACLSLITN NMVGAITGGL
   361  PELASRLTRI SAVLLEGMNK ETFNLKEVLN SIGIQTCVEV NKTLMERGLP TLNAEIQANL
   421  IGQFSSIEEE DNPIWSLIDK RIKLYMRRLL CLPSPQKCMP PMPGGLAVIQ QELEALGSQY
   481  ANIVNLNKQV YGPFYANILR KLLFNEEAMG KVDASPPTN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCP11L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 29 nTPM
  • esophagus: 22 nTPM
  • tongue: 22 nTPM
  • heart muscle: 21 nTPM
  • choroid plexus: 17 nTPM
  • skeletal muscle: 17 nTPM

Single-cell type

  • neutrophils: 227 nCPM
  • choroid plexus epithelial cells: 192 nCPM
  • esophageal apical cells: 170 nCPM
  • cardiomyocytes: 152 nCPM
  • neutrophil progenitors: 134 nCPM
  • oligodendrocytes: 122 nCPM

Immune cell

  • neutrophil: 67 nTPM
  • basophil: 30 nTPM
  • memory B-cell: 12 nTPM
  • naive CD4 T-cell: 12 nTPM
  • T-reg: 12 nTPM
  • eosinophil: 11 nTPM

Brain region

  • white matter: 228 nTPM
  • choroid plexus: 197 nTPM
  • medulla oblongata: 132 nTPM
  • basal ganglia: 118 nTPM
  • pons: 101 nTPM
  • midbrain: 99 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.26
gnomAD pLI
0
gnomAD missense Z
-0.13
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TCP11L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCP11L2 as an antibody target. Whether an autoantibody or antibody against TCP11L2 could matter depends on whether native TCP11L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCP11L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCP11L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TCP11L2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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