Seroatlas · Human Serome Atlas

DNAJA2

DnaJ homolog subfamily A member 2

Also known as: CPR3, DNAJ, DNJ3, DNJA2_HUMAN, HIRIP4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60884
Gene
DNAJA2
Ensembl
ENSG00000069345
Chromosome
16
Canonical length
412 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. The product of this gene works as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>O60884|DNAJA2
     1  MANVADTKLY DILGVPPGAS ENELKKAYRK LAKEYHPDKN PNAGDKFKEI SFAYEVLSNP
    61  EKRELYDRYG EQGLREGSGG GGGMDDIFSH IFGGGLFGFM GNQSRSRNGR RRGEDMMHPL
   121  KVSLEDLYNG KTTKLQLSKN VLCSACSGQG GKSGAVQKCS ACRGRGVRIM IRQLAPGMVQ
   181  QMQSVCSDCN GEGEVINEKD RCKKCEGKKV IKEVKILEVH VDKGMKHGQR ITFTGEADQA
   241  PGVEPGDIVL LLQEKEHEVF QRDGNDLHMT YKIGLVEALC GFQFTFKHLD GRQIVVKYPP
   301  GKVIEPGCVR VVRGEGMPQY RNPFEKGDLY IKFDVQFPEN NWINPDKLSE LEDLLPSRPE
   361  VPNIIGETEE VELQEFDSTR GSGGGQRREA YNDSSDEESS SHHGPGVQCA HQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 37 nTPM
  • tongue: 36 nTPM
  • heart muscle: 34 nTPM
  • liver: 34 nTPM
  • basal ganglia: 30 nTPM
  • cerebral cortex: 29 nTPM

Single-cell type

  • esophageal apical cells: 312 nCPM
  • oocytes: 304 nCPM
  • syncytiotrophoblasts: 214 nCPM
  • late primary spermatocytes: 193 nCPM
  • early primary spermatocytes: 161 nCPM
  • suprabasal keratinocytes: 140 nCPM

Immune cell

  • T-reg: 17 nTPM
  • eosinophil: 14 nTPM
  • memory CD4 T-cell: 13 nTPM
  • basophil: 13 nTPM
  • naive CD8 T-cell: 13 nTPM
  • MAIT T-cell: 13 nTPM

Brain region

  • cerebral cortex: 38 nTPM
  • cerebellum: 38 nTPM
  • basal ganglia: 35 nTPM
  • choroid plexus: 35 nTPM
  • hypothalamus: 34 nTPM
  • hippocampal formation: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.21
gnomAD pLI
1
gnomAD missense Z
2.48
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAJA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJA2 as an antibody target. Whether an autoantibody or antibody against DNAJA2 could matter depends on whether native DNAJA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAJA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DNAJA2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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