TUBB6

Protein identityUniProt · HPA

UniProt accession

Q9BUF5

Gene

TUBB6

Ensembl

ENSG00000176014

Chromosome

18

Canonical length

446 aa

Protein class

Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Microtubules,Cytokinetic bridge,Mitotic spindle,Primary cilium,Basal body,Flagellar centriole,Principal piece,End piece

OverviewNCBI Gene

Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in intercellular bridge; microtubule; and mitotic spindle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

446 residues, UniProt reviewed canonical sequence.

>Q9BUF5|TUBB6
     1  MREIVHIQAG QCGNQIGTKF WEVISDEHGI DPAGGYVGDS ALQLERINVY YNESSSQKYV
    61  PRAALVDLEP GTMDSVRSGP FGQLFRPDNF IFGQTGAGNN WAKGHYTEGA ELVDAVLDVV
   121  RKECEHCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEFP DRIMNTFSVM PSPKVSDTVV
   181  EPYNATLSVH QLVENTDETY CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTSL
   241  RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQMFDARNMM
   301  AACDPRHGRY LTVATVFRGP MSMKEVDEQM LAIQSKNSSY FVEWIPNNVK VAVCDIPPRG
   361  LKMASTFIGN STAIQELFKR ISEQFSAMFR RKAFLHWFTG EGMDEMEFTE AESNMNDLVS
   421  EYQQYQDATA NDGEEAFEDE EEEIDG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUBB6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.21

Highest tissue expression

221 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TUBB6.

Disease | AllUniProt

Conditions TUBB6 is implicated in, by any mechanism.

• Facial palsy, congenital, with ptosis and velopharyngeal dysfunction (FPVEPD) MIM:617732

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 70 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Facial palsy, congenital, with ptosis and velopharyngeal dysfunction
• Ptosis

Disease | ImmuneIEDB

Conditions an epitope on TUBB6 was assayed in.

• multiple sclerosis B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.04

gnomAD pLI

0

gnomAD missense Z

2.64

DepMap mean gene effect

0.09

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• microtubule cytoskeleton organization
• mitotic cell cycle

Molecular functions

• GTP binding
• GTPase activity
• metal ion binding
• structural constituent of cytoskeleton

Cellular components

• cytoplasm
• extracellular exosome
• intercellular bridge
• microtubule
• microtubule cytoskeleton
• mitotic spindle
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Tubulin
• Beta tubulin
• Tubulin/FtsZ, GTPase domain
• Tubulin/FtsZ, C-terminal
• Beta tubulin, autoregulation binding site
• Tubulin, conserved site
• Tubulin/FtsZ, 2-layer sandwich domain
• Tubulin, C-terminal
• Tubulin/FtsZ, GTPase domain superfamily
• Tubulin/FtsZ-like, C-terminal domain
• Tubulin/FtsZ family, GTPase domain
• Tubulin C-terminal domain

KeywordsUniProt

• Cytoplasm
• Cytoskeleton
• GTP-binding
• Isopeptide bond
• Magnesium
• Metal-binding
• Microtubule
• Nucleotide-binding
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of TUBB6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TUBA1B
• TUBB2A