Seroatlas · Human Serome Atlas

CPAP

Centrosomal P4.1-associated protein

Also known as: BM032, CENPJ, CPAP_HUMAN, LAP, LIP1, MCPH6, Sas-4, SASS4, SCKL4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HC77
Gene: CPAP
Ensembl: ENSG00000151849
Chromosome: 13
Canonical length: 1338 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Centrosome,Acrosome
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and cognitive disability. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

1338 residues, UniProt reviewed canonical sequence.

>Q9HC77|CPAP
     1  MFLMPTSSEL NSGQNFLTQW MTNPSRAGVI LNRGFPILEA DKEKRAAVDI STSFPIKGTH
    61  FSDSFSFINE EDSLLEEQKL ESNNPYKPQS DKSETHTAFP CIKKGPQVAA CHSAPGHQEE
   121  NKNDFIPDLA SEFKEGAYKD PLFKKLEQLK EVQQKKQEQL KRQQLEQLQR LMEEQEKLLT
   181  MVSGQCTLPG LSLLPDDQSQ KHRSPGNTTT GERATCCFPS YVYPDPTQEE TYPSNILSHE
   241  QSNFCRTAHG DFVLTSKRAS PNLFSEAQYQ EAPVEKNNLK EENRNHPTGE SILCWEKVTE
   301  QIQEANDKNL QKHDDSSEVA NIEERPIKAA IGERKQTFED YLEEQIQLEE QELKQKQLKE
   361  AEGPLPIKAK PKQPFLKRGE GLARFTNAKS KFQKGKESKL VTNQSTSEDQ PLFKMDRQQL
   421  QRKTALKNKE LCADNPILKK DSKARTKSGS VTLSQKPKML KCSNRKSLSP SGLKIQTGKK
   481  CDGQFRDQIK FENKVTSNNK ENVTECPKPC DTGCTGWNKT QGKDRLPLST GPASRLAAKS
   541  PIRETMKESE SSLDVSLQKK LETWEREKEK ENLELDEFLF LEQAADEISF SSNSSFVLKI
   601  LERDQQICKG HRMSSTPVKA VPQKTNPADP ISHCNRSEDL DHTAREKESE CEVAPKQLHS
   661  LSSADELREQ PCKIRKAVQK STSENQTEWN ARDDEGVPNS DSSTDSEEQL DVTIKPSTED
   721  RERGISSRED SPQVCDDKGP FKDTRTQEDK RRDVDLDLSD KDYSSDESIM ESIKHKVSEP
   781  SRSSSLSLSK MDFDDERTWT DLEENLCNHD VVLGNESTYG TPQTCYPNNE IGILDKTIKR
   841  KIAPVKRGED LSKSRRSRSP PTSELMMKFF PSLKPKPKSD SHLGNELKLN ISQDQPPGDN
   901  ARSQVLREKI IELETEIEKF KAENASLAKL RIERESALEK LRKEIADFEQ QKAKELARIE
   961  EFKKEEMRKL QKERKVFEKY TTAARTFPDK KEREEIQTLK QQIADLREDL KRKETKWSST
  1021  HSRLRSQIQM LVRENTDLRE EIKVMERFRL DAWKRAEAIE SSLEVEKKDK LANTSVRFQN
  1081  SQISSGTQVE KYKKNYLPMQ GNPPRRSKSA PPRDLGNLDK GQAASPREPL EPLNFPDPEY
  1141  KEEEEDQDIQ GEISHPDGKV EKVYKNGCRV ILFPNGTRKE VSADGKTITV TFFNGDVKQV
  1201  MPDQRVIYYY AAAQTTHTTY PEGLEVLHFS SGQIEKHYPD GRKEITFPDQ TVKNLFPDGQ
  1261  EESIFPDGTI VRVQRDGNKL IEFNNGQREL HTAQFKRREY PDGTVKTVYA NGHQETKYRS
  1321  GRIRVKDKEG NVLMDTEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

testis: 16 nTPM
thyroid gland: 10 nTPM
cerebellum: 8.9 nTPM
lymph node: 4.7 nTPM
skin: 4.7 nTPM
bone marrow: 4.1 nTPM

Single-cell type

early spermatids: 230 nCPM
megakaryocyte progenitors: 134 nCPM
early primary spermatocytes: 80 nCPM
monocyte progenitors: 66 nCPM
oligodendrocytes: 63 nCPM
late primary spermatocytes: 60 nCPM

Immune cell

eosinophil: 0.5 nTPM
intermediate monocyte: 0.1 nTPM
memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
NK-cell: 0.1 nTPM

Brain region

cerebellum: 9.2 nTPM
cerebral cortex: 5.9 nTPM
pons: 4.1 nTPM
thalamus: 3.8 nTPM
white matter: 3.8 nTPM
medulla oblongata: 3.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CPAP.

Disease | AllUniProt

Conditions CPAP is implicated in, by any mechanism.

Microcephaly 6, primary, autosomal recessive (MCPH6) MIM:608393
Seckel syndrome 4 (SCKL4) MIM:613676

Disease | GeneticClinVar

82 pathogenic / likely-pathogenic of 723 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Microcephaly 6, primary, autosomal recessive
Seckel syndrome 4
Microcephaly 1, primary, autosomal recessive
Perisylvian polymicrogyria
Lissencephaly type 3

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

TCP10L/CENPJ
Centromere protein J, C-terminal domain
T-complex protein 10, C-terminal domain superfamily
CENPJ, tubulin-binding region
T-complex protein 10 C-terminus
CPAP, tubulin-binding region

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CPAP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPAP as an antibody target. Whether an autoantibody or antibody against CPAP could matter depends on whether native CPAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPAP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CPAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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