Seroatlas · Human Serome Atlas

TUBB2A

Tubulin beta-2A chain

Also known as: dJ40E16.7, TBB2A_HUMAN, TUBB, TUBB2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13885
Gene
TUBB2A
Ensembl
ENSG00000137267
Chromosome
6
Canonical length
445 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Microtubules,Cytokinetic bridge,Mitotic spindle,Primary cilium,Basal body,Flagellar centriole,Principal piece,End piece

OverviewNCBI Gene

Microtubules, key participants in processes such as mitosis and intracellular transport, are composed of heterodimers of alpha- and beta-tubulins. The protein encoded by this gene is a beta-tubulin. Defects in this gene are associated with complex cortical dysplasia with other brain malformations-5. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

445 residues, UniProt reviewed canonical sequence.

>Q13885|TUBB2A
     1  MREIVHIQAG QCGNQIGAKF WEVISDEHGI DPTGSYHGDS DLQLERINVY YNEAAGNKYV
    61  PRAILVDLEP GTMDSVRSGP FGQIFRPDNF VFGQSGAGNN WAKGHYTEGA ELVDSVLDVV
   121  RKESESCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEYP DRIMNTFSVM PSPKVSDTVV
   181  EPYNATLSVH QLVENTDETY SIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTCL
   241  RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQMFDSKNMM
   301  AACDPRHGRY LTVAAIFRGR MSMKEVDEQM LNVQNKNSSY FVEWIPNNVK TAVCDIPPRG
   361  LKMSATFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS
   421  EYQQYQDATA DEQGEFEEEE GEDEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUBB2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
542 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 542 nTPM
  • hypothalamus: 486 nTPM
  • amygdala: 394 nTPM
  • hippocampal formation: 358 nTPM
  • midbrain: 350 nTPM
  • cerebellum: 335 nTPM

Single-cell type

  • esophageal apical cells: 539 nCPM
  • suprabasal keratinocytes: 422 nCPM
  • esophageal suprabasal cells: 414 nCPM
  • other brain neurons: 381 nCPM
  • platelets: 315 nCPM
  • breast myoepithelial cells: 296 nCPM

Immune cell

  • memory B-cell: 3.2 nTPM
  • T-reg: 3.2 nTPM
  • memory CD8 T-cell: 3.1 nTPM
  • MAIT T-cell: 2.4 nTPM
  • gdT-cell: 2.2 nTPM
  • memory CD4 T-cell: 2.1 nTPM

Brain region

  • hypothalamus: 788 nTPM
  • pons: 727 nTPM
  • cerebral cortex: 599 nTPM
  • basal ganglia: 562 nTPM
  • medulla oblongata: 516 nTPM
  • midbrain: 461 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TUBB2A.

Disease | AllUniProt

Conditions TUBB2A is implicated in, by any mechanism.

  • Cortical dysplasia, complex, with other brain malformations 5 (CDCBM5) MIM:615763

Disease | GeneticClinVar

36 pathogenic / likely-pathogenic of 373 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on TUBB2A was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.93
gnomAD missense Z
5.26
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TUBB2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUBB2A as an antibody target. Whether an autoantibody or antibody against TUBB2A could matter depends on whether native TUBB2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUBB2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TUBB2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TUBB2A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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