Seroatlas · Human Serome Atlas

TUBB4B

Tubulin beta-4B chain

Also known as: Beta2, TBB4B_HUMAN, TUBB2C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P68371
Gene
TUBB4B
Ensembl
ENSG00000188229
Chromosome
9
Canonical length
445 aa
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Microtubules,Cytokinetic bridge,Mitotic spindle,Primary cilium,Basal body,Principal piece,End piece

OverviewNCBI Gene

Enables double-stranded RNA binding activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in axonemal microtubule; intercellular bridge; and mitotic spindle. Implicated in Leber congenital amaurosis with early-onset deafness. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

445 residues, UniProt reviewed canonical sequence.

>P68371|TUBB4B
     1  MREIVHLQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLERINVY YNEATGGKYV
    61  PRAVLVDLEP GTMDSVRSGP FGQIFRPDNF VFGQSGAGNN WAKGHYTEGA ELVDSVLDVV
   121  RKEAESCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEYP DRIMNTFSVV PSPKVSDTVV
   181  EPYNATLSVH QLVENTDETY CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTCL
   241  RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQMFDAKNMM
   301  AACDPRHGRY LTVAAVFRGR MSMKEVDEQM LNVQNKNSSY FVEWIPNNVK TAVCDIPPRG
   361  LKMSATFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS
   421  EYQQYQDATA EEEGEFEEEA EEEVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUBB4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
767 nTPM

Expression across tissuesHPA

Tissue

  • testis: 767 nTPM
  • choroid plexus: 735 nTPM
  • fallopian tube: 477 nTPM
  • heart muscle: 438 nTPM
  • bone marrow: 400 nTPM
  • esophagus: 352 nTPM

Single-cell type

  • late spermatids: 4,004 nCPM
  • late primary spermatocytes: 3,642 nCPM
  • respiratory ciliated cells: 2,677 nCPM
  • fallopian tube ciliated cells: 2,625 nCPM
  • esophageal apical cells: 2,024 nCPM
  • early spermatids: 2,019 nCPM

Immune cell

  • basophil: 96 nTPM
  • neutrophil: 57 nTPM
  • T-reg: 45 nTPM
  • eosinophil: 43 nTPM
  • gdT-cell: 41 nTPM
  • MAIT T-cell: 38 nTPM

Brain region

  • choroid plexus: 886 nTPM
  • midbrain: 360 nTPM
  • pons: 318 nTPM
  • medulla oblongata: 290 nTPM
  • hypothalamus: 265 nTPM
  • thalamus: 263 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TUBB4B.

Disease | AllUniProt

Conditions TUBB4B is implicated in, by any mechanism.

  • Leber congenital amaurosis with early-onset deafness (LCAEOD) MIM:617879

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 168 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on TUBB4B was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.81
gnomAD missense Z
4.5
DepMap mean gene effect
-0.42
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TUBB4B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUBB4B as an antibody target. Whether an autoantibody or antibody against TUBB4B could matter depends on whether native TUBB4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUBB4B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TUBB4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TUBB4B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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