Seroatlas · Human Serome Atlas

HDDC3

Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

Also known as: MESH1, MESH1_HUMAN, MGC45386

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4P3
Gene: HDDC3
Ensembl: ENSG00000184508
Chromosome: 15
Canonical length: 179 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

179 residues, UniProt reviewed canonical sequence.

>Q8N4P3|HDDC3
     1  MGSEAAQLLE AADFAARKHR QQRRKDPEGT PYINHPIGVA RILTHEAGIT DIVVLQAALL
    61  HDTVEDTDTT LDEVELHFGA QVRRLVEEVT DDKTLPKLER KRLQVEQAPH SSPGAKLVKL
   121  ADKLYNLRDL NRCTPEGWSE HRVQEYFEWA AQVVKGLQGT NRQLEEALKH LFKQRGLTI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HDDC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 19 nTPM
pancreas: 19 nTPM
choroid plexus: 16 nTPM
kidney: 16 nTPM
basal ganglia: 15 nTPM
cerebral cortex: 15 nTPM

Single-cell type

megakaryocytes: 74 nCPM
hofbauer cells: 60 nCPM
cytotrophoblasts: 57 nCPM
epididymal principal cells: 54 nCPM
enterocytes: 53 nCPM
migrating cytotrophoblasts: 51 nCPM

Immune cell

plasmacytoid DC: 44 nTPM
memory B-cell: 35 nTPM
naive CD4 T-cell: 35 nTPM
T-reg: 32 nTPM
naive B-cell: 32 nTPM
NK-cell: 32 nTPM

Brain region

cerebral cortex: 15 nTPM
thalamus: 15 nTPM
amygdala: 13 nTPM
white matter: 13 nTPM
spinal cord: 13 nTPM
medulla oblongata: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0.02
gnomAD missense Z: 0.39
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

metal ion binding
guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity

Protein domainsUniProt · Pfam · InterPro

HD/PDEase domain
HD domain
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
HD domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HDDC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TNIP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HDDC3 as an antibody target. Whether an autoantibody or antibody against HDDC3 could matter depends on whether native HDDC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HDDC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HDDC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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