Seroatlas · Human Serome Atlas

NME7

Nucleoside diphosphate kinase homolog 7

Also known as: CFAP67, FLJ37194, NDK7_HUMAN, NM23-H7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5B8
Gene
NME7
Ensembl
ENSG00000143156
Chromosome
1
Canonical length
376 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the non-metastatic expressed family of nucleoside diphosphate kinases. Members of this family are enzymes that catalyzes phosphate transfer from nucleoside triphosphates to nucleoside diphosphates. This protein contains two kinase domains, one of which is involved in autophosphorylation and the other may be inactive. This protein localizes to the centrosome and functions as a component of the gamma-tubulin ring complex which plays a role in microtubule organization. Mutations in this gene may be associated with venous thromboembolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>Q9Y5B8|NME7
     1  MNHSERFVFI AEWYDPNASL LRRYELLFYP GDGSVEMHDV KNHRTFLKRT KYDNLHLEDL
    61  FIGNKVNVFS RQLVLIDYGD QYTARQLGSR KEKTLALIKP DAISKAGEII EIINKAGFTI
   121  TKLKMMMLSR KEALDFHVDH QSRPFFNELI QFITTGPIIA MEILRDDAIC EWKRLLGPAN
   181  SGVARTDASE SIRALFGTDG IRNAAHGPDS FASAAREMEL FFPSSGGCGP ANTAKFTNCT
   241  CCIVKPHAVS EGLLGKILMA IRDAGFEISA MQMFNMDRVN VEEFYEVYKG VVTEYHDMVT
   301  EMYSGPCVAM EIQQNNATKT FREFCGPADP EIARHLRPGT LRAIFGKTKI QNAVHCTDLP
   361  EDGLLEVQYF FKILDN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NME7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 26 nTPM
  • retina: 18 nTPM
  • parathyroid gland: 17 nTPM
  • pituitary gland: 15 nTPM
  • testis: 15 nTPM
  • ovary: 14 nTPM

Single-cell type

  • ependymal cells: 394 nCPM
  • respiratory ciliated cells: 372 nCPM
  • epicardial cells: 366 nCPM
  • lactotrophs: 337 nCPM
  • rod photoreceptor cells: 330 nCPM
  • somatotrophs: 327 nCPM

Immune cell

  • T-reg: 15 nTPM
  • memory CD4 T-cell: 12 nTPM
  • MAIT T-cell: 12 nTPM
  • naive CD8 T-cell: 12 nTPM
  • NK-cell: 11 nTPM
  • naive CD4 T-cell: 10 nTPM

Brain region

  • choroid plexus: 12 nTPM
  • hypothalamus: 9.8 nTPM
  • hippocampal formation: 9.6 nTPM
  • medulla oblongata: 8.8 nTPM
  • midbrain: 8.4 nTPM
  • cerebral cortex: 7.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0
gnomAD missense Z
0.5
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NME7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NME7 as an antibody target. Whether an autoantibody or antibody against NME7 could matter depends on whether native NME7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NME7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NME7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NME7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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