Seroatlas · Human Serome Atlas

SELPLG

P-selectin glycoprotein ligand 1

Also known as: CD162, PSGL-1, SELPL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14242
Gene: SELPLG
Ensembl: ENSG00000110876
Chromosome: 12
Canonical length: 412 aa
Protein class: Candidate cardiovascular disease genes, CD markers, Plasma proteins, Predicted membrane proteins
Subcellular location: Vesicles
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>Q14242|SELPLG
     1  MPLQLLLLLI LLGPGNSLQL WDTWADEAEK ALGPLLARDR RQATEYEYLD YDFLPETEPP
    61  EMLRNSTDTT PLTGPGTPES TTVEPAARRS TGLDAGGAVT ELTTELANMG NLSTDSAAME
   121  IQTTQPAATE AQTTQPVPTE AQTTPLAATE AQTTRLTATE AQTTPLAATE AQTTPPAATE
   181  AQTTQPTGLE AQTTAPAAME AQTTAPAAME AQTTPPAAME AQTTQTTAME AQTTAPEATE
   241  AQTTQPTATE AQTTPLAAME ALSTEPSATE ALSMEPTTKR GLFIPFSVSS VTHKGIPMAA
   301  SNLSVNYPVG APDHISVKQC LLAILILALV ATIFFVCTVV LAVRLSRKGH MYPVRNYSPT
   361  EMVCISSLLP DGGEGPSATA NGGLSKAKSP GLTPEPREDR EGDDLTLHSF LP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SELPLG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

spleen: 75 nTPM
lymph node: 58 nTPM
thymus: 49 nTPM
appendix: 45 nTPM
lung: 38 nTPM
tonsil: 29 nTPM

Single-cell type

neutrophils: 449 nCPM
pdcs: 193 nCPM
microglia: 141 nCPM
nk-cells: 110 nCPM
monocytes: 83 nCPM
monocyte progenitors: 79 nCPM

Immune cell

basophil: 1,548 nTPM
neutrophil: 1,262 nTPM
total PBMC: 1,035 nTPM
eosinophil: 942 nTPM
non-classical monocyte: 767 nTPM
T-reg: 664 nTPM

Brain region

white matter: 47 nTPM
medulla oblongata: 32 nTPM
thalamus: 32 nTPM
spinal cord: 31 nTPM
pons: 26 nTPM
hypothalamus: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0.18
gnomAD missense Z: -0.1
DepMap mean gene effect: 0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

P-selectin glycoprotein ligand 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SELPLG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SELPLG as an antibody target. Whether an autoantibody or antibody against SELPLG could matter depends on whether native SELPLG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SELPLG is annotated at the cell surface, where native SELPLG is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SELPLG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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