Seroatlas · Human Serome Atlas

CCNG1

Cyclin-G1

Also known as: CCNG, CCNG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51959
Gene
CCNG1
Ensembl
ENSG00000113328
Chromosome
5
Canonical length
295 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

295 residues, UniProt reviewed canonical sequence.

>P51959|CCNG1
     1  MIEVLTTTDS QKLLHQLNAL LEQESRCQPK VCGLRLIESA HDNGLRMTAR LRDFEVKDLL
    61  SLTQFFGFDT ETFSLAVNLL DRFLSKMKVQ PKHLGCVGLS CFYLAVKSIE EERNVPLATD
   121  LIRISQYRFT VSDLMRMEKI VLEKVCWKVK ATTAFQFLQL YYSLLQENLP LERRNSINFE
   181  RLEAQLKACH CRIIFSKAKP SVLALSIIAL EIQAQKCVEL TEGIECLQKH SKINGRDLTF
   241  WQELVSKCLT EYSSNKCSKP NVQKLKWIVS GRTARQLKHS YYRITHLPTI PEMVP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
153 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 153 nTPM
  • duodenum: 129 nTPM
  • liver: 121 nTPM
  • kidney: 115 nTPM
  • tongue: 113 nTPM
  • ovary: 105 nTPM

Single-cell type

  • platelets: 567 nCPM
  • enterocytes: 236 nCPM
  • esophageal apical cells: 198 nCPM
  • migrating cytotrophoblasts: 194 nCPM
  • enteric transient amplifying cells: 192 nCPM
  • enteric stem cells: 191 nCPM

Immune cell

  • naive CD4 T-cell: 85 nTPM
  • T-reg: 81 nTPM
  • naive CD8 T-cell: 72 nTPM
  • total PBMC: 64 nTPM
  • memory CD4 T-cell: 63 nTPM
  • myeloid DC: 60 nTPM

Brain region

  • white matter: 40 nTPM
  • choroid plexus: 40 nTPM
  • medulla oblongata: 34 nTPM
  • spinal cord: 32 nTPM
  • hypothalamus: 31 nTPM
  • cerebellum: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
gnomAD missense Z
0.76
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCNG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNG1 as an antibody target. Whether an autoantibody or antibody against CCNG1 could matter depends on whether native CCNG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCNG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCNG1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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