Seroatlas · Human Serome Atlas

SPATA2

Spermatogenesis-associated protein 2

Also known as: KIAA0757, PD1, PPP1R145, SPAT2_HUMAN, tamo

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UM82
Gene: SPATA2
Ensembl: ENSG00000158480
Chromosome: 20
Canonical length: 520 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Enables signaling receptor complex adaptor activity and ubiquitin-specific protease binding activity. Involved in several processes, including protein deubiquitination; regulation of necroptotic process; and regulation of tumor necrosis factor-mediated signaling pathway. Located in cytoplasm; fibrillar center; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>Q9UM82|SPATA2
     1  MGKPSSMDTK FKDDLFRKYV QFHESKVDTT TSRQRPGSDE CLRVAASTLL SLHKVDPFYR
    61  FRLIQFYEVV ESSLRSLSSS SLRALHGAFS MLETVGINLF LYPWKKEFRS IKTYTGPFVY
   121  YVKSTLLEED IRAILSCMGY TPELGTAYKL RELVETLQVK MVSFELFLAK VECEQMLEIH
   181  SQVKDKGYSE LDIVSERKSS AEDVRGCSDA LRRRAEGREH LTASMSRVAL QKSASERAAK
   241  DYYKPRVTKP SRSVDAYDSY WESRKPPLKA SLSLRKEPVA TDVGDDLKDE IIRPSPSLLT
   301  MASSPHGSPD VLPPASPSNG PALLRGTYFS TQDDVDLYTD SEPRATYRRQ DALRPDVWLL
   361  RNDAHSLYHK RSPPAKESAL SKCQSCGLSC SSSLCQRCDS LLTCPPASKP SAFPSKASTH
   421  DSLAHGASLR EKYPGQTQGL DRLPHLHSKS KPSTTPTSRC GFCNRPGATN TCTQCSKVSC
   481  DACLSAYHYD PCYKKSELHK FMPNNQLNYK STQLSHLVYR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 22 nTPM
spinal cord: 21 nTPM
basal ganglia: 17 nTPM
cerebellum: 15 nTPM
hippocampal formation: 14 nTPM
midbrain: 14 nTPM

Single-cell type

late spermatids: 95 nCPM
late primary spermatocytes: 84 nCPM
syncytiotrophoblasts: 40 nCPM
early spermatids: 39 nCPM
colonocytes: 29 nCPM
goblet cells: 25 nCPM

Immune cell

neutrophil: 2.6 nTPM
naive B-cell: 2.1 nTPM
naive CD8 T-cell: 1.9 nTPM
memory CD8 T-cell: 1.7 nTPM
naive CD4 T-cell: 1.6 nTPM
classical monocyte: 1.5 nTPM

Brain region

basal ganglia: 40 nTPM
white matter: 39 nTPM
thalamus: 39 nTPM
hippocampal formation: 39 nTPM
cerebral cortex: 38 nTPM
amygdala: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.29
gnomAD pLI: 0.98
gnomAD missense Z: 0.68
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPATA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA2 as an antibody target. Whether an autoantibody or antibody against SPATA2 could matter depends on whether native SPATA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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