Seroatlas · Human Serome Atlas

PIP4P1

Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

Also known as: C14orf9, MGC26684, PP4P1_HUMAN, TMEM55B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86T03
Gene: PIP4P1
Ensembl: ENSG00000165782
Chromosome: 14
Canonical length: 277 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

277 residues, UniProt reviewed canonical sequence.

>Q86T03|PIP4P1
     1  MAADGERSPL LSEPIDGGAG GNGLVGPGGS GAGPGGGLTP SAPPYGAAFP PFPEGHPAVL
    61  PGEDPPPYSP LTSPDSGSAP MITCRVCQSL INVEGKMHQH VVKCGVCNEA TPIKNAPPGK
   121  KYVRCPCNCL LICKVTSQRI ACPRPYCKRI INLGPVHPGP LSPEPQPMGV RVICGHCKNT
   181  FLWTEFTDRT LARCPHCRKV SSIGRRYPRK RCICCFLLGL LLAVTATGLA FGTWKHARRY
   241  GGIYAAWAFV ILLAVLCLGR ALYWACMKVS HPVQNFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIP4P1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 46 nTPM
cerebral cortex: 40 nTPM
skeletal muscle: 34 nTPM
skin: 33 nTPM
cerebellum: 32 nTPM
hypothalamus: 31 nTPM

Single-cell type

syncytiotrophoblasts: 204 nCPM
cytotrophoblasts: 93 nCPM
oocytes: 78 nCPM
esophageal apical cells: 74 nCPM
hofbauer cells: 71 nCPM
migrating cytotrophoblasts: 56 nCPM

Immune cell

memory B-cell: 13 nTPM
plasmacytoid DC: 10 nTPM
naive B-cell: 10 nTPM
eosinophil: 7.3 nTPM
naive CD8 T-cell: 6.1 nTPM
naive CD4 T-cell: 5.8 nTPM

Brain region

pons: 33 nTPM
hypothalamus: 30 nTPM
cerebral cortex: 29 nTPM
thalamus: 29 nTPM
basal ganglia: 28 nTPM
midbrain: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.87
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

5-bisphosphate 4-phosphatase activity
phosphatidylinositol-4

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PIP4P1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIP4P1 as an antibody target. Whether an autoantibody or antibody against PIP4P1 could matter depends on whether native PIP4P1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIP4P1 is annotated at the cell surface, where native PIP4P1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PIP4P1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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