Seroatlas · Human Serome Atlas

GPR137B

Integral membrane protein GPR137B

Also known as: G137B_HUMAN, TM7SF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60478
Gene: GPR137B
Ensembl: ENSG00000077585
Chromosome: 1
Canonical length: 399 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Involved in positive regulation of TORC1 signaling; positive regulation of protein localization to lysosome; and regulation of autophagy. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

399 residues, UniProt reviewed canonical sequence.

>O60478|GPR137B
     1  MRPERPRPRG SAPGPMETPP WDPARNDSLP PTLTPAVPPY VKLGLTVVYT VFYALLFVFI
    61  YVQLWLVLRY RHKRLSYQSV FLFLCLFWAS LRTVLFSFYF KDFVAANSLS PFVFWLLYCF
   121  PVCLQFFTLT LMNLYFTQVI FKAKSKYSPE LLKYRLPLYL ASLFISLVFL LVNLTCAVLV
   181  KTGNWERKVI VSVRVAINDT LFVLCAVSLS ICLYKISKMS LANIYLESKG SSVCQVTAIG
   241  VTVILLYTSR ACYNLFILSF SQNKSVHSFD YDWYNVSDQA DLKNQLGDAG YVLFGVVLFV
   301  WELLPTTLVV YFFRVRNPTK DLTNPGMVPS HGFSPRSYFF DNPRRYDSDD DLAWNIAPQG
   361  LQGGFAPDYY DWGQQTNSFL AQAGTLQDST LDPDKPSLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR137B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 126 nTPM

Expression across tissuesHPA

Tissue

retina: 126 nTPM
kidney: 64 nTPM
basal ganglia: 43 nTPM
epididymis: 38 nTPM
amygdala: 35 nTPM
spinal cord: 34 nTPM

Single-cell type

rod photoreceptor cells: 394 nCPM
melanocytes: 318 nCPM
müller glia: 315 nCPM
kupffer cells: 266 nCPM
cdc: 264 nCPM
hofbauer cells: 237 nCPM

Immune cell

basophil: 18 nTPM
eosinophil: 9.6 nTPM
non-classical monocyte: 7.3 nTPM
intermediate monocyte: 4.1 nTPM
memory CD8 T-cell: 2.7 nTPM
T-reg: 1.7 nTPM

Brain region

basal ganglia: 54 nTPM
midbrain: 52 nTPM
thalamus: 51 nTPM
medulla oblongata: 51 nTPM
white matter: 51 nTPM
hypothalamus: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.32
gnomAD pLI: 0
gnomAD missense Z: -0.24
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Integral membrane protein GPR137

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPR137B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR137B as an antibody target. Whether an autoantibody or antibody against GPR137B could matter depends on whether native GPR137B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR137B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPR137B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...