Seroatlas · Human Serome Atlas

SESN3

Sestrin-3

Also known as: MGC29667, SESN3_HUMAN, SEST3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P58005
Gene
SESN3
Ensembl
ENSG00000149212
Chromosome
11
Canonical length
492 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

Canonical amino-acid sequenceUniProt

492 residues, UniProt reviewed canonical sequence.

>P58005|SESN3
     1  MNRGGGSPSA AANYLLCTNC RKVLRKDKRI RVSQPLTRGP SAFIPEKEVV QANTVDERTN
    61  FLVEEYSTSG RLDNITQVMS LHTQYLESFL RSQFYMLRMD GPLPLPYRHY IAIMAAARHQ
   121  CSYLINMHVD EFLKTGGIAE WLNGLEYVPQ RLKNLNEINK LLAHRPWLIT KEHIQKLVKT
   181  GENNWSLPEL VHAVVLLAHY HALASFVFGS GINPERDPEI SNGFRLISVN NFCVCDLAND
   241  NNIENASLSG SNFGIVDSLS ELEALMERMK RLQEEREDEE ASQEEMSTRF EKEKKESLFV
   301  VSGDTFHSFP HSDFEDDMII TSDVSRYIED PGFGYEDFAR RGEEHLPTFR AQDYTWENHG
   361  FSLVNRLYSD IGHLLDEKFR MVYNLTYNTM ATHEDVDTTM LRRALFNYVH CMFGIRYDDY
   421  DYGEVNQLLE RSLKVYIKTV TCYPERTTKR MYDSYWRQFK HSEKVHVNLL LMEARMQAEL
   481  LYALRAITRH LT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SESN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
54 nTPM

Expression across tissuesHPA

Tissue

  • testis: 54 nTPM
  • basal ganglia: 30 nTPM
  • parathyroid gland: 24 nTPM
  • lymph node: 23 nTPM
  • tonsil: 23 nTPM
  • ovary: 23 nTPM

Single-cell type

  • late spermatids: 826 nCPM
  • early spermatids: 804 nCPM
  • retinal pigment epithelial cells: 456 nCPM
  • late primary spermatocytes: 364 nCPM
  • b-cells: 347 nCPM
  • pituicytes/fscs: 269 nCPM

Immune cell

  • memory B-cell: 1.8 nTPM
  • T-reg: 1.7 nTPM
  • naive CD4 T-cell: 1.6 nTPM
  • non-classical monocyte: 1.5 nTPM
  • naive B-cell: 1.1 nTPM
  • memory CD4 T-cell: 0.9 nTPM

Brain region

  • basal ganglia: 141 nTPM
  • thalamus: 139 nTPM
  • amygdala: 113 nTPM
  • midbrain: 110 nTPM
  • cerebral cortex: 102 nTPM
  • hypothalamus: 88 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.68
gnomAD missense Z
2.61
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SESN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SESN3 as an antibody target. Whether an autoantibody or antibody against SESN3 could matter depends on whether native SESN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SESN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SESN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SESN3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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