Seroatlas · Human Serome Atlas

RNF152

E3 ubiquitin-protein ligase RNF152

Also known as: FLJ39176, RN152_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N8N0
Gene
RNF152
Ensembl
ENSG00000176641
Chromosome
18
Canonical length
203 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables small GTPase binding activity and ubiquitin protein ligase activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of TORC1 signaling; and protein ubiquitination. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

203 residues, UniProt reviewed canonical sequence.

>Q8N8N0|RNF152
     1  METLSQDSLL ECQICFNYYS PRRRPKLLDC KHTCCSVCLQ QMRTSQKDVR CPWCRGVTKL
    61  PPGFSVSQLP DDPEVLAVIA IPHTSEHTPV FIKLPSNGCY MLPLPISKER ALLPGDMGCR
   121  LLPGSQQKSV TVVTIPAEQQ PLQGGAPQEA VEEEQDRRGV VKSSTWSGVC TVILVACVLV
   181  FLLGIVLHNM SCISKRFTVI SCG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF152 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
53 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 53 nTPM
  • liver: 21 nTPM
  • blood vessel: 18 nTPM
  • cerebellum: 16 nTPM
  • salivary gland: 14 nTPM
  • skin: 12 nTPM

Single-cell type

  • renal collecting duct intercalated cells: 1,618 nCPM
  • proximal tubule cells: 1,091 nCPM
  • choroid plexus epithelial cells: 654 nCPM
  • salivary ionocytes: 523 nCPM
  • lacrimal acinar cells: 367 nCPM
  • pericytes: 365 nCPM

Immune cell

  • basophil: 0.3 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • choroid plexus: 143 nTPM
  • cerebellum: 112 nTPM
  • pons: 71 nTPM
  • thalamus: 56 nTPM
  • medulla oblongata: 53 nTPM
  • white matter: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0.13
gnomAD missense Z
0.65
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF152 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF152 as an antibody target. Whether an autoantibody or antibody against RNF152 could matter depends on whether native RNF152 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF152 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF152 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RNF152. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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