Seroatlas · Human Serome Atlas

SLC38A9

Neutral amino acid transporter 9

Also known as: FLJ90709, S38A9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NBW4
Gene
SLC38A9
Ensembl
ENSG00000177058
Chromosome
5
Canonical length
561 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Vesicles

OverviewNCBI Gene

Enables several functions, including L-amino acid transmembrane transporter activity; cholesterol binding activity; and guanyl-nucleotide exchange factor activity. Involved in carboxylic acid transport; cellular response to amino acid stimulus; and positive regulation of TORC1 signaling. Located in Ragulator complex; late endosome; and lysosomal membrane. Part of FNIP-folliculin RagC/D GAP. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

561 residues, UniProt reviewed canonical sequence.

>Q8NBW4|SLC38A9
     1  MANMNSDSRH LGTSEVDHER DPGPMNIQFE PSDLRSKRPF CIEPTNIVNV NHVIQRVSDH
    61  ASAMNKRIHY YSRLTTPADK ALIAPDHVVP APEECYVYSP LGSAYKLQSY TEGYGKNTSL
   121  VTIFMIWNTM MGTSILSIPW GIKQAGFTTG MCVIILMGLL TLYCCYRVVK SRTMMFSLDT
   181  TSWEYPDVCR HYFGSFGQWS SLLFSLVSLI GAMIVYWVLM SNFLFNTGKF IFNFIHHIND
   241  TDTILSTNNS NPVICPSAGS GGHPDNSSMI FYANDTGAQQ FEKWWDKSRT VPFYLVGLLL
   301  PLLNFKSPSF FSKFNILGTV SVLYLIFLVT FKAVRLGFHL EFHWFIPTEF FVPEIRFQFP
   361  QLTGVLTLAF FIHNCIITLL KNNKKQENNV RDLCIAYMLV TLTYLYIGVL VFASFPSPPL
   421  SKDCIEQNFL DNFPSSDTLS FIARIFLLFQ MMTVYPLLGY LARVQLLGHI FGDIYPSIFH
   481  VLILNLIIVG AGVIMACFYP NIGGIIRYSG AACGLAFVFI YPSLIYIISL HQEERLTWPK
   541  LIFHVFIIIL GVANLIVQFF M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC38A9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
54 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 54 nTPM
  • testis: 18 nTPM
  • liver: 16 nTPM
  • tonsil: 14 nTPM
  • pancreas: 12 nTPM
  • lymph node: 11 nTPM

Single-cell type

  • syncytiotrophoblasts: 1,294 nCPM
  • migrating cytotrophoblasts: 411 nCPM
  • cytotrophoblasts: 382 nCPM
  • early spermatids: 337 nCPM
  • late primary spermatocytes: 164 nCPM
  • microglia: 157 nCPM

Immune cell

  • classical monocyte: 9.5 nTPM
  • intermediate monocyte: 8.8 nTPM
  • myeloid DC: 8.4 nTPM
  • plasmacytoid DC: 8 nTPM
  • NK-cell: 7.7 nTPM
  • MAIT T-cell: 7.5 nTPM

Brain region

  • white matter: 24 nTPM
  • cerebellum: 23 nTPM
  • basal ganglia: 21 nTPM
  • medulla oblongata: 20 nTPM
  • thalamus: 20 nTPM
  • hypothalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.29
gnomAD missense Z
1.48
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC38A9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC38A9 as an antibody target. Whether an autoantibody or antibody against SLC38A9 could matter depends on whether native SLC38A9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC38A9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC38A9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC38A9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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