Seroatlas · Human Serome Atlas

UBE2F

NEDD8-conjugating enzyme UBE2F

Also known as: NCE2, UBE2F_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969M7
Gene: UBE2F
Ensembl: ENSG00000184182
Chromosome: 2
Canonical length: 185 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables NEDD8 conjugating enzyme activity. Involved in protein neddylation. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

185 residues, UniProt reviewed canonical sequence.

>Q969M7|UBE2F
     1  MLTLASKLKR DDGLKGSRTA ATASDSTRRV SVRDKLLVKE VAELEANLPC TCKVHFPDPN
    61  KLHCFQLTVT PDEGYYQGGK FQFETEVPDA YNMVPPKVKC LTKIWHPNIT ETGEICLSLL
   121  REHSIDGTGW APTRTLKDVV WGLNSLFTDL LNFDDPLNIE AAEHHLRDKE DFRNKVDDYI
   181  KRYAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

pancreas: 67 nTPM
tongue: 64 nTPM
skeletal muscle: 59 nTPM
heart muscle: 55 nTPM
epididymis: 50 nTPM
choroid plexus: 47 nTPM

Single-cell type

microglia: 85 nCPM
megakaryocytes: 62 nCPM
late spermatids: 57 nCPM
oligodendrocytes: 48 nCPM
choroid plexus epithelial cells: 38 nCPM
extravillous trophoblasts: 38 nCPM

Immune cell

basophil: 113 nTPM
NK-cell: 103 nTPM
non-classical monocyte: 79 nTPM
intermediate monocyte: 68 nTPM
gdT-cell: 67 nTPM
eosinophil: 64 nTPM

Brain region

pons: 32 nTPM
white matter: 31 nTPM
hypothalamus: 31 nTPM
midbrain: 30 nTPM
medulla oblongata: 29 nTPM
cerebellum: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.92
gnomAD missense Z: 1.33
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2F in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RBX2
UBA3
RNF7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2F as an antibody target. Whether an autoantibody or antibody against UBE2F could matter depends on whether native UBE2F is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2F is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2F as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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