Seroatlas · Human Serome Atlas

CDC34

Ubiquitin-conjugating enzyme E2 R1

Also known as: E2-CDC34, UB2R1_HUMAN, UBC3, UBE2R1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49427
Gene: CDC34
Ensembl: ENSG00000099804
Chromosome: 19
Canonical length: 236 aa
Protein class: Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

236 residues, UniProt reviewed canonical sequence.

>P49427|CDC34
     1  MARPLVPSSQ KALLLELKGL QEEPVEGFRV TLVDEGDLYN WEVAIFGPPN TYYEGGYFKA
    61  RLKFPIDYPY SPPAFRFLTK MWHPNIYETG DVCISILHPP VDDPQSGELP SERWNPTQNV
   121  RTILLSVISL LNEPNTFSPA NVDASVMYRK WKESKGKDRE YTDIIRKQVL GTKVDAERDG
   181  VKVPTTLAEY CVKTKAPAPD EGSDLFYDDY YEDGEVEEEA DSCFGDDEDD SGTEES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 108 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 108 nTPM
testis: 101 nTPM
liver: 92 nTPM
heart muscle: 81 nTPM
cerebellum: 67 nTPM
colon: 64 nTPM

Single-cell type

late spermatids: 385 nCPM
erythrocytes: 109 nCPM
esophageal apical cells: 90 nCPM
early spermatids: 88 nCPM
breast lactating cells: 70 nCPM
extravillous trophoblasts: 69 nCPM

Immune cell

neutrophil: 8.2 nTPM
eosinophil: 4.7 nTPM
non-classical monocyte: 3.5 nTPM
basophil: 3.2 nTPM
memory CD8 T-cell: 2.9 nTPM
intermediate monocyte: 2.7 nTPM

Brain region

cerebral cortex: 58 nTPM
thalamus: 50 nTPM
white matter: 50 nTPM
hippocampal formation: 49 nTPM
amygdala: 49 nTPM
cerebellum: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.31
gnomAD pLI: 0.96
gnomAD missense Z: 1.83
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDC34 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC34 as an antibody target. Whether an autoantibody or antibody against CDC34 could matter depends on whether native CDC34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC34 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDC34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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