Seroatlas · Human Serome Atlas

UBE2M

NEDD8-conjugating enzyme Ubc12

Also known as: hUbc12, UBC12, UBC12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P61081
Gene
UBE2M
Ensembl
ENSG00000130725
Chromosome
19
Canonical length
183 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Nuclear bodies,Cytosol

OverviewNCBI Gene

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>P61081|UBE2M
     1  MIKLFSLKQQ KKEEESAGGT KGSSKKASAA QLRIQKDINE LNLPKTCDIS FSDPDDLLNF
    61  KLVICPDEGF YKSGKFVFSF KVGQGYPHDP PKVKCETMVY HPNIDLEGNV CLNILREDWK
   121  PVLTINSIIY GLQYLFLEPN PEDPLNKEAA EVLQNNRRLF EQNVQRSMRG GYIGSTYFER
   181  CLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2M can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
219 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 219 nTPM
  • amygdala: 194 nTPM
  • skeletal muscle: 170 nTPM
  • basal ganglia: 140 nTPM
  • hippocampal formation: 130 nTPM
  • heart muscle: 129 nTPM

Single-cell type

  • megakaryocytes: 161 nCPM
  • breast lactating cells: 133 nCPM
  • alveolar cells type 2: 116 nCPM
  • suprabasal keratinocytes: 116 nCPM
  • erythrocyte progenitors: 115 nCPM
  • smooth muscle cells: 107 nCPM

Immune cell

  • neutrophil: 10 nTPM
  • basophil: 6.8 nTPM
  • plasmacytoid DC: 6.7 nTPM
  • eosinophil: 4.2 nTPM
  • naive B-cell: 3.8 nTPM
  • classical monocyte: 3.6 nTPM

Brain region

  • cerebral cortex: 178 nTPM
  • white matter: 155 nTPM
  • basal ganglia: 151 nTPM
  • amygdala: 142 nTPM
  • hypothalamus: 140 nTPM
  • pons: 138 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.8
gnomAD missense Z
2.29
DepMap mean gene effect
-1.21
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2M in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2M as an antibody target. Whether an autoantibody or antibody against UBE2M could matter depends on whether native UBE2M is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2M is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2M as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBE2M. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...