Seroatlas · Human Serome Atlas

TUSC2

Tumor suppressor candidate 2

Also known as: C3orf11, FUS1, PAP, PDAP2, TUSC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75896
Gene: TUSC2
Ensembl: ENSG00000114383
Chromosome: 3
Canonical length: 110 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Predicted to be involved in inflammatory response and regulation of mitochondrial membrane potential. Predicted to act upstream of or within several processes, including natural killer cell differentiation; neutrophil-mediated killing of gram-negative bacterium; and regulation of cytokine production. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

110 residues, UniProt reviewed canonical sequence.

>O75896|TUSC2
     1  MGASGSKARG LWPFASAAGG GGSEAAGAEQ ALVRPRGRAV PPFVFTRRGS MFYDEDGDLA
    61  HEFYEETIVT KNGQKRAKLR RVHKNLIPQG IVKLDHPRIH VDFPVILYEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUSC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 60 nTPM
skeletal muscle: 50 nTPM
amygdala: 50 nTPM
basal ganglia: 47 nTPM
hippocampal formation: 47 nTPM
hypothalamus: 44 nTPM

Single-cell type

late spermatids: 584 nCPM
esophageal suprabasal cells: 161 nCPM
esophageal apical cells: 140 nCPM
late primary spermatocytes: 115 nCPM
early spermatids: 114 nCPM
oocytes: 101 nCPM

Immune cell

eosinophil: 35 nTPM
total PBMC: 32 nTPM
neutrophil: 30 nTPM
plasmacytoid DC: 26 nTPM
memory CD8 T-cell: 25 nTPM
naive CD8 T-cell: 25 nTPM

Brain region

midbrain: 49 nTPM
thalamus: 49 nTPM
pons: 47 nTPM
hypothalamus: 47 nTPM
cerebral cortex: 45 nTPM
medulla oblongata: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.77
gnomAD missense Z: 1.07
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

Tumour suppressor candidate 2
Tumour suppressor candidate 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TUSC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUSC2 as an antibody target. Whether an autoantibody or antibody against TUSC2 could matter depends on whether native TUSC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUSC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TUSC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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