Seroatlas · Human Serome Atlas

ZC3H10

Zinc finger CCCH domain-containing protein 10

Also known as: FLJ14451, ZC3HA_HUMAN, ZC3HDC10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96K80
Gene: ZC3H10
Ensembl: ENSG00000135482
Chromosome: 12
Canonical length: 434 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables miRNA binding activity. Involved in negative regulation of miRNA processing. Acts upstream of with a positive effect on post-transcriptional regulation of gene expression. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

434 residues, UniProt reviewed canonical sequence.

>Q96K80|ZC3H10
     1  MPDRDSYANG TGSSGGGPGG GGSEEASGAG VGSGGASSDA ICRDFLRNVC KRGKRCRYRH
    61  PDMSEVSNLG VSKNEFIFCH DFQNKECSRP NCRFIHGSKE DEDGYKKTGE LPPRLRQKVA
   121  AGLGLSPADL PNGKEEVPIC RDFLKGDCQR GAKCKFRHLQ RDFEFDARGG GGTGGGSTGS
   181  VLPGRRHDLY DIYDLPDRGF EDHEPGPKRR RGGCCPPDGP HFESYEYSLA PPRGVECRLL
   241  EEENAMLRKR VEELKKQVSN LLATNEVLLE QNAQFRNQAK VITLSSTAPA TEQTLAPTVG
   301  TVATFNHGIA QTHTTLSSQA LQPRPVSQQE LVAPAGAPAA PPTNAAPPAA PPPPPPHLTP
   361  EITPLSAALA QTIAQGMAPP PVSMAPVAVS VAPVAPVAVS MAQPLAGITM SHTTTPMVTY
   421  PIASQSMRIT AMPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC3H10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 8.1 nTPM

Expression across tissuesHPA

Tissue

testis: 8.1 nTPM
skeletal muscle: 4.7 nTPM
retina: 3.7 nTPM
spleen: 3.6 nTPM
blood vessel: 3.5 nTPM
endometrium: 3.5 nTPM

Single-cell type

early spermatids: 2.5 nCPM
late spermatids: 1.5 nCPM
myosatellite cells: 1.2 nCPM
epididymal principal cells: 0.5 nCPM
epididymal efferent duct ciliated cells: 0.4 nCPM
late primary spermatocytes: 0.4 nCPM

Immune cell

non-classical monocyte: 11 nTPM
NK-cell: 8.1 nTPM
intermediate monocyte: 6 nTPM
eosinophil: 5.9 nTPM
myeloid DC: 5.3 nTPM
classical monocyte: 5 nTPM

Brain region

white matter: 11 nTPM
cerebellum: 9.5 nTPM
medulla oblongata: 8.7 nTPM
basal ganglia: 8.2 nTPM
pons: 8.2 nTPM
cerebral cortex: 8.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0.32
gnomAD missense Z: 2.28
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZC3H10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC3H10 as an antibody target. Whether an autoantibody or antibody against ZC3H10 could matter depends on whether native ZC3H10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC3H10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC3H10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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