Seroatlas · Human Serome Atlas

INIP

SOSS complex subunit C

Also known as: C9orf80, HSPC043, hSSBIP1, MISE, SOSS-C, SOSSC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRY2
Gene: INIP
Ensembl: ENSG00000148153
Chromosome: 9
Canonical length: 104 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a subunit of single-stranded DNA binding complexes that are important for maintaining genome stability. These complexes are involved in G2/M checkpoint control and homologous recombination repair. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

104 residues, UniProt reviewed canonical sequence.

>Q9NRY2|INIP
     1  MAANSSGQGF QNKNRVAILA ELDKEKRKLL MQNQSSTNHP GASIALSRPS LNKDFRDHAE
    61  QQHIAAQQKA ALQHAHAHSS GYFITQDSAF GNLILPVLPR LDPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

lymph node: 14 nTPM
thymus: 14 nTPM
tonsil: 13 nTPM
spinal cord: 12 nTPM
cerebral cortex: 11 nTPM
rectum: 11 nTPM

Single-cell type

neutrophils: 52 nCPM
epididymal principal cells: 49 nCPM
monocyte progenitors: 46 nCPM
cdc: 45 nCPM
extravillous trophoblasts: 45 nCPM
megakaryocytes: 43 nCPM

Immune cell

eosinophil: 33 nTPM
basophil: 30 nTPM
intermediate monocyte: 29 nTPM
myeloid DC: 27 nTPM
non-classical monocyte: 27 nTPM
classical monocyte: 25 nTPM

Brain region

white matter: 35 nTPM
basal ganglia: 26 nTPM
cerebral cortex: 25 nTPM
hypothalamus: 24 nTPM
cerebellum: 24 nTPM
thalamus: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0.03
gnomAD missense Z: 1.27
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

SOSS complex subunit C
SOSS complex subunit C

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INIP as an antibody target. Whether an autoantibody or antibody against INIP could matter depends on whether native INIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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