Seroatlas · Human Serome Atlas

SMUG1

Single-strand selective monofunctional uracil DNA glycosylase

Also known as: FDG, HMUDG, SMUG1_HUMAN, UNG3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q53HV7
Gene
SMUG1
Ensembl
ENSG00000123415
Chromosome
12
Canonical length
270 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature is known for some but not all of the variants. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

270 residues, UniProt reviewed canonical sequence.

>Q53HV7|SMUG1
     1  MPQAFLLGSI HEPAGALMEP QPCPGSLAES FLEEELRLNA ELSQLQFSEP VGIIYNPVEY
    61  AWEPHRNYVT RYCQGPKEVL FLGMNPGPFG MAQTGVPFGE VSMVRDWLGI VGPVLTPPQE
   121  HPKRPVLGLE CPQSEVSGAR FWGFFRNLCG QPEVFFHHCF VHNLCPLLFL APSGRNLTPA
   181  ELPAKQREQL LGICDAALCR QVQLLGVRLV VGVGRLAEQR ARRALAGLMP EVQVEGLLHP
   241  SPRNPQANKG WEAVAKERLN ELGLLPLLLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMUG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • liver: 45 nTPM
  • epididymis: 38 nTPM
  • choroid plexus: 35 nTPM
  • esophagus: 34 nTPM
  • kidney: 32 nTPM
  • stomach: 29 nTPM

Single-cell type

  • esophageal apical cells: 167 nCPM
  • extravillous trophoblasts: 123 nCPM
  • esophageal suprabasal cells: 118 nCPM
  • syncytiotrophoblasts: 115 nCPM
  • migrating cytotrophoblasts: 110 nCPM
  • cytotrophoblasts: 107 nCPM

Immune cell

  • basophil: 90 nTPM
  • eosinophil: 57 nTPM
  • memory B-cell: 50 nTPM
  • classical monocyte: 46 nTPM
  • neutrophil: 46 nTPM
  • plasmacytoid DC: 46 nTPM

Brain region

  • white matter: 35 nTPM
  • medulla oblongata: 35 nTPM
  • choroid plexus: 33 nTPM
  • thalamus: 33 nTPM
  • spinal cord: 32 nTPM
  • basal ganglia: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
0.86
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SMUG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMUG1 as an antibody target. Whether an autoantibody or antibody against SMUG1 could matter depends on whether native SMUG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMUG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SMUG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMUG1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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