Seroatlas · Human Serome Atlas

TBXA2R

Thromboxane A2 receptor

Also known as: TA2R_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P21731
Gene
TBXA2R
Ensembl
ENSG00000006638
Chromosome
19
Canonical length
343 aa
Protein class
Disease related genes, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins
Subcellular location
Nuclear speckles,Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

343 residues, UniProt reviewed canonical sequence.

>P21731|TBXA2R
     1  MWPNGSSLGP CFRPTNITLE ERRLIASPWF AASFCVVGLA SNLLALSVLA GARQGGSHTR
    61  SSFLTFLCGL VLTDFLGLLV TGTIVVSQHA ALFEWHAVDP GCRLCRFMGV VMIFFGLSPL
   121  LLGAAMASER YLGITRPFSR PAVASQRRAW ATVGLVWAAA LALGLLPLLG VGRYTVQYPG
   181  SWCFLTLGAE SGDVAFGLLF SMLGGLSVGL SFLLNTVSVA TLCHVYHGQE AAQQRPRDSE
   241  VEMMAQLLGI MVVASVCWLP LLVFIAQTVL RNPPAMSPAG QLSRTTEKEL LIYLRVATWN
   301  QILDPWVYIL FRRAVLRRLQ PRLSTRPRSL SLQPQLTQRS GLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBXA2R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 35 nTPM
  • adrenal gland: 8.4 nTPM
  • spleen: 6.7 nTPM
  • kidney: 6 nTPM
  • liver: 5.9 nTPM
  • heart muscle: 5.1 nTPM

Single-cell type

  • platelets: 361 nCPM
  • megakaryocytes: 93 nCPM
  • hepatic stellate cells: 65 nCPM
  • megakaryocyte progenitors: 18 nCPM
  • smooth muscle cells: 18 nCPM
  • podocytes: 16 nCPM

Immune cell

  • naive B-cell: 11 nTPM
  • naive CD8 T-cell: 9.3 nTPM
  • naive CD4 T-cell: 4.2 nTPM
  • neutrophil: 4 nTPM
  • total PBMC: 4 nTPM
  • basophil: 3.6 nTPM

Brain region

  • white matter: 6.3 nTPM
  • cerebellum: 5.9 nTPM
  • medulla oblongata: 5.7 nTPM
  • pons: 5.2 nTPM
  • cerebral cortex: 5.1 nTPM
  • thalamus: 5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TBXA2R.

Disease | AllUniProt

Conditions TBXA2R is implicated in, by any mechanism.

  • Bleeding disorder, platelet-type, 13 (BDPLT13) MIM:614009

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 259 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.36
gnomAD pLI
0
gnomAD missense Z
1.07
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TBXA2R in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBXA2R as an antibody target. Whether an autoantibody or antibody against TBXA2R could matter depends on whether native TBXA2R is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBXA2R is annotated at the cell surface, where native TBXA2R is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TBXA2R as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TBXA2R. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...