Seroatlas · Human Serome Atlas

ZNF366

Zinc finger protein 366

Also known as: FLJ39796, ZN366_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N895
Gene: ZNF366
Ensembl: ENSG00000178175
Chromosome: 5
Canonical length: 744 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables nuclear estrogen receptor binding activity and transcription corepressor activity. Involved in negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of transcription by RNA polymerase II; and response to estrogen. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

744 residues, UniProt reviewed canonical sequence.

>Q8N895|ZNF366
     1  MQKEMKMIKD EDVHFDLAVK KTPSFPHCLQ PVASRGKAPQ RHPFPEALRG PFSQFRYEPP
    61  PGDLDGFPGV FEGAGSRKRK SMPTKMPYNH PAEEVTLALH SEENKNHGLP NLPLLFPQPP
   121  RPKYDSQMID LCNVGFQFYR SLEHFGGKPV KQEPIKPSAV WPQPTPTPFL PTPYPYYPKV
   181  HPGLMFPFFV PSSSPFPFSR HTFLPKQPPE PLLPRKAEPQ ESEETKQKVE RVDVNVQIDD
   241  SYYVDVGGSQ KRWQCPTCEK SYTSKYNLVT HILGHSGIKP HACTHCGKLF KQLSHLHTHM
   301  LTHQGTRPHK CQVCHKAFTQ TSHLKRHMMQ HSEVKPHNCR VCGRGFAYPS ELKAHEAKHA
   361  SGRENICVEC GLDFPTLAQL KRHLTTHRGP IQYNCSECDK TFQYPSQLQN HMMKHKDIRP
   421  YICSECGMEF VQPHHLKQHS LTHKGVKEHK CGICGREFTL LANMKRHVLI HTNIRAYQCH
   481  LCYKSFVQKQ TLKAHMIVHS DVKPFKCKLC GKEFNRMHNL MGHMHLHSDS KPFKCLYCPS
   541  KFTLKGNLTR HMKVKHGVME RGLHSQGLGR GRIALAQTAG VLRSLEQEEP FDLSQKRRAK
   601  VPVFQSDGES AQGSHCHEEE EEDNCYEVEP YSPGLAPQSQ QLCTPEDLST KSEHAPEVLE
   661  EACKEEKEDA SKGEWEKRSK GDLGAEGGQE RDCAGRDECL SLRAFQSTRR GPSFSDYLYF
   721  KHRDESLKEL LERKMEKQAV LLGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF366 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 8.4 nTPM

Expression across tissuesHPA

Tissue

placenta: 8.4 nTPM
spleen: 6 nTPM
adipose tissue: 5.5 nTPM
tongue: 5.2 nTPM
lymph node: 4.7 nTPM
skeletal muscle: 4.7 nTPM

Single-cell type

cone photoreceptor cells: 153 nCPM
vascular endothelial cells: 100 nCPM
cdc: 85 nCPM
monocyte progenitors: 22 nCPM
kupffer cells: 18 nCPM
macrophages: 16 nCPM

Immune cell

myeloid DC: 10 nTPM
classical monocyte: 1 nTPM
total PBMC: 0.5 nTPM
intermediate monocyte: 0.4 nTPM
plasmacytoid DC: 0.3 nTPM
neutrophil: 0.2 nTPM

Brain region

thalamus: 12 nTPM
amygdala: 10 nTPM
pons: 10 nTPM
medulla oblongata: 9.5 nTPM
midbrain: 8.8 nTPM
cerebral cortex: 8.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.07
gnomAD missense Z: -0.06
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF366 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF366 as an antibody target. Whether an autoantibody or antibody against ZNF366 could matter depends on whether native ZNF366 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF366 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF366 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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