Seroatlas · Human Serome Atlas

SH2D4A

SH2 domain-containing protein 4A

Also known as: FLJ20967, PPP1R38, SH24A_HUMAN, SH2A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H788
Gene: SH2D4A
Ensembl: ENSG00000104611
Chromosome: 8
Canonical length: 454 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables phosphatase binding activity. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

454 residues, UniProt reviewed canonical sequence.

>Q9H788|SH2D4A
     1  MLKQILSEMY IDPDLLAELS EEQKQILFFK MREEQIRRWK EREAAMERKE SLPVKPRPKK
    61  ENGKSVHWKL GADKEVWVWV MGEHHLDKPY DVLCNEIIAE RARLKAEQEA EEPRKTHSEE
   121  FTNSLKTKSQ YHDLQAPDNQ QTKDIWKKVA EKEELEQGSR PAPTLEEEKI RSLSSSSRNI
   181  QQMLADSINR MKAYAFHQKK ESMKKKQDEE INQIEEERTK QICKSWKEDS EWQASLRKSK
   241  AADEKRRSLA KQAREDYKRL SLGAQKGRGG ERLQSPLRVP QKPERPPLPP KPQFLNSGAY
   301  PQKPLRNQGV VRTLSSSAQE DIIRWFKEEQ LPLRAGYQKT SDTIAPWFHG ILTLKKANEL
   361  LLSTGMPGSF LIRVSERIKG YALSYLSEDG CKHFLIDASA DAYSFLGVDQ LQHATLADLV
   421  EYHKEEPITS LGKELLLYPC GQQDQLPDYL ELFE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH2D4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

liver: 37 nTPM
stomach: 28 nTPM
ovary: 25 nTPM
salivary gland: 23 nTPM
esophagus: 20 nTPM
urinary bladder: 17 nTPM

Single-cell type

oocytes: 212 nCPM
salivary duct cells: 182 nCPM
renal collecting duct intercalated cells: 169 nCPM
esophageal apical cells: 153 nCPM
salivary ionocytes: 142 nCPM
cytotrophoblasts: 137 nCPM

Immune cell

neutrophil: 1.8 nTPM
myeloid DC: 0.5 nTPM
naive B-cell: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM
NK-cell: 0.1 nTPM

Brain region

choroid plexus: 4.5 nTPM
white matter: 4.5 nTPM
medulla oblongata: 4.4 nTPM
midbrain: 4.1 nTPM
amygdala: 3.9 nTPM
hippocampal formation: 3.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: -2.17
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

phosphatase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SH2D4A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SH2D4A as an antibody target. Whether an autoantibody or antibody against SH2D4A could matter depends on whether native SH2D4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SH2D4A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SH2D4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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