Seroatlas · Human Serome Atlas

PPP1R12C

Protein phosphatase 1 regulatory subunit 12C

Also known as: AAVS1, DKFZP434D0412, LENG3, MBS85, p84, p85, PP12C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZL4
Gene: PPP1R12C
Ensembl: ENSG00000125503
Chromosome: 19
Canonical length: 782 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

Canonical amino-acid sequenceUniProt

782 residues, UniProt reviewed canonical sequence.

>Q9BZL4|PPP1R12C
     1  MSGEDGPAAG PGAAAAAARE RRREQLRQWG ARAGAEPGPG ERRARTVRFE RAAEFLAACA
    61  GGDLDEARLM LRAADPGPGA ELDPAAPPPA RAVLDSTNAD GISALHQACI DENLEVVRFL
   121  VEQGATVNQA DNEGWTPLHV AASCGYLDIA RYLLSHGANI AAVNSDGDLP LDLAESDAME
   181  GLLKAEIARR GVDVEAAKRA EEELLLHDTR CWLNGGAMPE ARHPRTGASA LHVAAAKGYI
   241  EVMRLLLQAG YDPELRDGDG WTPLHAAAHW GVEDACRLLA EHGGGMDSLT HAGQRPCDLA
   301  DEEVLSLLEE LARKQEDLRN QKEASQSRGQ EPQAPSSSKH RRSSVCRLSS REKISLQDLS
   361  KERRPGGAGG PPIQDEDEGE EGPTEPPPAE PRTLNGVSSP PHPSPKSPVQ LEEAPFSRRF
   421  GLLKTGSSGA LGPPERRTAE GAPGAGLQRS ASSSWLEGTS TQAKELRLAR ITPTPSPKLP
   481  EPSVLSEVTK PPPCLENSSP PSRIPEPESP AKPNVPTAST APPADSRDRR RSYQMPVRDE
   541  ESESQRKARS RLMRQSRRST QGVTLTDLKE AEKAAGKAPE SEKPAQSLDP SRRPRVPGVE
   601  NSDSPAQRAE APDGQGPGPQ AAREHRKVGK EWRGPAEGEE AEPADRSQES STLEGGPSAR
   661  RQRWQRDLNP EPEPESEEPD GGFRTLYAEL RRENERLREA LTETTLRLAQ LKVELERATQ
   721  RQERFAERPA LLELERFERR ALERKAAELE EELKALSDLR ADNQRLKDEN AALIRVISKL
   781  SK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R12C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 302 nTPM

Expression across tissuesHPA

Tissue

colon: 302 nTPM
heart muscle: 276 nTPM
endometrium: 191 nTPM
blood vessel: 188 nTPM
cervix: 179 nTPM
urinary bladder: 172 nTPM

Single-cell type

vascular smooth muscle cells: 89 nCPM
smooth muscle cells: 75 nCPM
choroid plexus epithelial cells: 68 nCPM
tuft cells: 58 nCPM
neutrophils: 57 nCPM
megakaryocytes: 50 nCPM

Immune cell

eosinophil: 2.6 nTPM
naive B-cell: 2.5 nTPM
non-classical monocyte: 2.4 nTPM
neutrophil: 1.6 nTPM
classical monocyte: 1.5 nTPM
plasmacytoid DC: 1.5 nTPM

Brain region

medulla oblongata: 128 nTPM
cerebral cortex: 126 nTPM
choroid plexus: 125 nTPM
pons: 116 nTPM
thalamus: 115 nTPM
amygdala: 113 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.09
gnomAD missense Z: 1.63
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R12C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R12C as an antibody target. Whether an autoantibody or antibody against PPP1R12C could matter depends on whether native PPP1R12C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R12C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R12C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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