Seroatlas · Human Serome Atlas

CCDC85C

Coiled-coil domain-containing protein 85C

Also known as: CC85C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NKD9
Gene: CCDC85C
Ensembl: ENSG00000205476
Chromosome: 14
Canonical length: 419 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cell Junctions

OverviewNCBI Gene

Predicted to be involved in cerebral cortex development. Predicted to act upstream of or within several processes, including Notch signaling pathway; establishment of cell polarity; and radial glial cell differentiation. Located in adherens junction and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

419 residues, UniProt reviewed canonical sequence.

>A6NKD9|CCDC85C
     1  MAKPAATAAA ASEELSQVPD EELLRWSKEE LARRLRRAEG EKVGLMLEHG GLMRDVNRRL
    61  QQHLLEIRGL KDVNQRLQDD NQELRELCCF LDDDRQKGRK LAREWQRFGR HAAGAVWHEV
   121  ARSQQKLREL EARQEALLRE NLELKELVLL LDEERAALAA TGAASGGGGG GGGAGSRSSI
   181  DSQASLSGPL SGGAPGAGAR DVGDGSSTSS AGSGGSPDHH HHVPPPLLPP GPHKAPDGKA
   241  GATRRSLDDL SAPPHHRSIP NGLHDPSSTY IRQLESKVRL LEGDKLLAQQ AGSGEFRTLR
   301  KGFSPYHSES QLASLPPSYQ DSLQNGPACP APELPSPPSA GYSPAGQKPE AVVHAMKVLE
   361  VHENLDRQLQ DSCEEDLSEK EKAIVREMCN VVWRKLGDAA SSKPSIRQHL SGNQFKGPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC85C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 73 nTPM
retina: 32 nTPM
colon: 30 nTPM
cerebral cortex: 28 nTPM
esophagus: 27 nTPM
basal ganglia: 25 nTPM

Single-cell type

epicardial cells: 164 nCPM
podocytes: 127 nCPM
esophageal apical cells: 101 nCPM
rod photoreceptor cells: 95 nCPM
cone photoreceptor cells: 91 nCPM
endometrial luminal cells: 88 nCPM

Immune cell

naive CD4 T-cell: 0.4 nTPM
T-reg: 0.4 nTPM
memory CD4 T-cell: 0.3 nTPM
memory CD8 T-cell: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM
basophil: 0.1 nTPM

Brain region

cerebellum: 146 nTPM
basal ganglia: 62 nTPM
medulla oblongata: 59 nTPM
thalamus: 54 nTPM
pons: 51 nTPM
amygdala: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.75
gnomAD missense Z: 1.35
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC85C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PPP1CB

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC85C as an antibody target. Whether an autoantibody or antibody against CCDC85C could matter depends on whether native CCDC85C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC85C is annotated at the cell surface, where native CCDC85C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CCDC85C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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