Seroatlas · Human Serome Atlas

TASOR

Protein TASOR

Also known as: C3orf63, FAM208A, KIAA1105, RAP140, se89-1, TASOR_HUMAN, TASOR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UK61
Gene: TASOR
Ensembl: ENSG00000163946
Chromosome: 3
Canonical length: 1670 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables chromatin binding activity. Involved in protein localization to heterochromatin and transposable element silencing by heterochromatin formation. Located in heterochromatin and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1670 residues, UniProt reviewed canonical sequence.

>Q9UK61|TASOR
     1  MATAVETEAC QPTDASWESG GGGDDEMKQA LPELESSQQN GGGGGLNIAE PSGGAGREEN
    61  AGAEAAQSLS HEQPQDSSEA GAAALPRGPE EPERPVRRSF QIPRKSREKK ALFQPLTPGS
   121  REFEDVVNIL HSSYLEPTSV TNFNYRRACL VHNELLEKEF TEKRRELKFD GRLDKELSES
   181  YAFLMVDRYQ VQTICEKGLH VGQSKITILG SPSMGVYLSR YADLLQANPL DTGAMGDVVI
   241  FKIMKGKIKS IYDPMGVKSL ESMLNKSALD PTPKHECHVS KNANRITSLL AYRAYELTQY
   301  YFYEYGFDEL RRRPRHVCPY AVVSFTYKDD IQTPKFVPSS RSNSFNTDRN IDKYNYTLWK
   361  GQLLNKGKLL CYISLRSATR AFLPIKLPEK LDVETVMSID HLKQKIPPAL FYKETYLGPN
   421  EVLKNGMYCS LYEVVEKTRI GSNMESLLQK LDREKLVLVK PLGDRGYLFL LSPYQMVPPY
   481  EYQTAKSRVL HALFLFQEPR SIVTSQKGST NAAPQERHES MPDVLKIAQF LQFSLIQCRK
   541  EFKNISAINF HSVVEKYVSE FFKRGFGSGK REFIMFPYDS RLDDKKFLYS APRNKSHIDT
   601  CLHAYIFRPE VYQLPICKLK ELFEENRKLQ QFSPLSDYEG QEEEMNGTKM KFGKRNNSRG
   661  EAIISGKQRS SHSLDYDKDR VKELINLIQC RKKSVGGDSD TEDMRSKTVL KRKLEDLPEN
   721  MRKLAKTSNL SENCHLYEES PQPIGSLGHD ADLRRQQQDT CNSGIADIHR LFNWLSETLA
   781  NARHSDASLT DTVNKALGLS TDDAYEELRQ KHEYELNSTP DKKDYEQPTC AKVENAQFKG
   841  TQSLLLEVDA TSKYSVAIST SEVGTDHKLH LKEDPNLISV NNFEDCSLCP SVPIEHGFRR
   901  QQSKSNNVEE TEIHWKLIPI TGGNARSPED QLGKHGEKQT PGMKSPEEQL VCVPPQEAFP
   961  NDPRVINRQR SSDYQFPSSP FTDTLKGTTE DDVLTGQVEE QCVPAAEAEP PAVSETTERT
  1021  VLGEYNLFSR KIEEILKQKN VSYVSTVSTP IFSTQEKMKR LSEFIYSKTS KAGVQEFVDG
  1081  LHEKLNTIII KASAKGGNLP PVSPNDSGAK IASNPLERHV IPVSSSDFNN KHLLEPLCSD
  1141  PLKDTNSDEQ HSTSALTEVE MNQPQHATEL MVTSDHIVPG DMAREPVEET TKSPSDVNIS
  1201  AQPALSNFIS QLEPEVFNSL VKIMKDVQKN TVKFYIHEEE ESVLCKEIKE YLIKLGNTEC
  1261  HPEQFLERRS KLDKLLIIIQ NEDIAGFIHK IPGLVTLKKL PCVSFAGVDS LDDVKNHTYN
  1321  ELFVSGGFIV SDESILNPEV VTVENLKNFL TFLEELSTPE GKWQWKVHCK FQKKLKELGR
  1381  LNAKALSLLT LLNVYQKKHL VEILSYHNCD SQTRNAPELD CLIRLQAQNI QQRHIVFLTE
  1441  KNIKMLSSYT DNGIVVATAE DFMQNFKNLV GYHNSITEEN LPQLGANENL ESQSALLEND
  1501  EKDEEDMSLD SGDEISHIEV CSNFHSEIWE KETKGSRGTD QKKNTQIELQ SSPDVQNSLL
  1561  EDKTYLDSEE RTSIDIVCSE GENSNSTEQD SYSNFQVYHS QLNMSHQFSH FNVLTHQTFL
  1621  GTPYALSSSQ SQENENYFLS AYTESLDRDK SPPPLSWGKS DSSRPYSQEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TASOR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

testis: 29 nTPM
thymus: 21 nTPM
parathyroid gland: 20 nTPM
lymph node: 20 nTPM
tonsil: 18 nTPM
thyroid gland: 18 nTPM

Single-cell type

cardiomyocytes: 176 nCPM
neutrophil progenitors: 154 nCPM
thyrotrophs: 151 nCPM
lactotrophs: 137 nCPM
podocytes: 128 nCPM
corticotrophs: 122 nCPM

Immune cell

gdT-cell: 1.5 nTPM
memory CD8 T-cell: 1.5 nTPM
naive CD4 T-cell: 1.4 nTPM
naive CD8 T-cell: 1.4 nTPM
eosinophil: 1.3 nTPM
memory CD4 T-cell: 1.3 nTPM

Brain region

white matter: 49 nTPM
cerebellum: 45 nTPM
basal ganglia: 43 nTPM
spinal cord: 39 nTPM
medulla oblongata: 38 nTPM
midbrain: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 1
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TASOR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TASOR as an antibody target. Whether an autoantibody or antibody against TASOR could matter depends on whether native TASOR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TASOR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TASOR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...