Seroatlas · Human Serome Atlas

PHAX

Phosphorylated adapter RNA export protein

Also known as: FLJ13193, PHAX_HUMAN, RNUXA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H814
Gene
PHAX
Ensembl
ENSG00000164902
Chromosome
5
Canonical length
394 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables mRNA cap binding complex binding activity. Involved in RNA stabilization. Located in nucleoplasm. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

394 residues, UniProt reviewed canonical sequence.

>Q9H814|PHAX
     1  MALEVGDMED GQLSDSDSDM TVAPSDRPLQ LPKVLGGDSA MRAFQNTATA CAPVSHYRAV
    61  ESVDSSEESF SDSDDDSCLW KRKRQKCFNP PPKPEPFQFG QSSQKPPVAG GKKINNIWGA
   121  VLQEQNQDAV ATELGILGME GTIDRSRQSE TYNYLLAKKL RKESQEHTKD LDKELDEYMH
   181  GGKKMGSKEE ENGQGHLKRK RPVKDRLGNR PEMNYKGRYE ITAEDSQEKV ADEISFRLQE
   241  PKKDLIARVV RIIGNKKAIE LLMETAEVEQ NGGLFIMNGS RRRTPGGVFL NLLKNTPSIS
   301  EEQIKDIFYI ENQKEYENKK AARKRRTQVL GKKMKQAIKS LNFQEDDDTS RETFASDTNE
   361  ALASLDESQE GHAEAKLEAE EAIEVDHSHD LDIF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHAX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 15 nTPM
  • cerebellum: 14 nTPM
  • amygdala: 14 nTPM
  • basal ganglia: 13 nTPM
  • midbrain: 13 nTPM
  • hippocampal formation: 13 nTPM

Single-cell type

  • differentiating spermatogonia: 89 nCPM
  • early primary spermatocytes: 82 nCPM
  • esophageal suprabasal cells: 71 nCPM
  • migrating cytotrophoblasts: 68 nCPM
  • undifferentiated spermatogonia: 65 nCPM
  • cytotrophoblasts: 65 nCPM

Immune cell

  • NK-cell: 11 nTPM
  • basophil: 8.6 nTPM
  • naive CD8 T-cell: 8.2 nTPM
  • memory B-cell: 8.1 nTPM
  • MAIT T-cell: 8 nTPM
  • naive CD4 T-cell: 7.8 nTPM

Brain region

  • cerebellum: 26 nTPM
  • white matter: 24 nTPM
  • cerebral cortex: 23 nTPM
  • thalamus: 23 nTPM
  • hippocampal formation: 22 nTPM
  • amygdala: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.94
gnomAD pLI
0
gnomAD missense Z
0.48
DepMap mean gene effect
-1.13
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Phosphorylated adapter RNA export protein, RNA-binding domain
  • Phosphorylated adapter RNA export protein, RNA-binding domain superfamily
  • Phosphorylated adapter RNA export protein
  • Phosphorylated adapter RNA export protein, RNA-binding domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PHAX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHAX as an antibody target. Whether an autoantibody or antibody against PHAX could matter depends on whether native PHAX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHAX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHAX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PHAX. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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