Cold-shock domain
IPR011129
Definition
A conserved domain of about 70 amino acids has been found in prokaryotic and eukaryotic single-strand nucleic-acid binding proteins [[cite:PMID:1622933], [cite:PMID:2184368], [cite:PMID:8022259], [cite:PMID:9586995], [cite:PMID:10446180]]. This domain, which is known as the 'cold-shock domain' (CSD) is present in the proteins listed below. Escherichia coli protein CS7.4 (gene cspA) which is induced in response to low temperature (cold-shock protein) and which binds to and stimulates the transcription of the CCAAT-containing promoters of the HN-S protein and of gyrA. Transcription termination factor Rho, a prokaryotic protein which facilitates transcription termination. Mammalian Y box binding protein 1 (YB1). A protein that binds to the CCAAT-containing Y box of mammalian HLA class II genes. Xenopus Y box binding proteins -1 and -2 (Y1 and Y2). Proteins that bind to the CCAAT-containing Y box of Xenopus hsp70 genes. Xenopus B box binding protein (YB3). YB3 binds the B box promoter element of genes transcribed by RNA polymerase III. Enhancer factor I subunit A (EFI-A) (dbpB). A protein that also bind to CCAAT-motif in various gene promoters. DbpA, a human DNA-binding protein of unknown specificity. Bacillus subtilis cold-shock proteins cspB and cspC. Streptomyces clavuligerus protein SC 7.0. E. coli proteins cspB, cspC, cspD, cspE and cspF. Unr, a mammalian gene encoded upstream of the N-ras gene. Unr contains nine repeats that are similar to the CSD domain. The function of Unr is not yet known but it could be a multivalent DNA-binding protein. PPPin, a mammalian brain-specific protein that binds to histone mRNA and which is thought to play a role in the regulation of brain development.
8 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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