Seroatlas · Human Serome Atlas

GADD45GIP1

Large ribosomal subunit protein mL64

Also known as: CKBBP2, CKbetaBP2, CRIF1, G45IP_HUMAN, MGC4667, MGC4758, PLINP-1, Plinp1, PRG6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAE8
Gene: GADD45GIP1
Ensembl: ENSG00000179271
Chromosome: 19
Canonical length: 222 aa
Protein class: Predicted intracellular proteins, Ribosomal proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

222 residues, UniProt reviewed canonical sequence.

>Q8TAE8|GADD45GIP1
     1  MAASVRQARS LLGVAATLAP GSRGYRARPP PRRRPGPRWP DPEDLLTPRW QLGPRYAAKQ
    61  FARYGAASGV VPGSLWPSPE QLRELEAEER EWYPSLATMQ ESLRVKQLAE EQKRREREQH
   121  IAECMAKMPQ MIVNWQQQQR ENWEKAQADK ERRARLQAEA QELLGYQVDP RSARFQELLQ
   181  DLEKKERKRL KEEKQKRKKE ARAAALAAAV AQDPAASGAP SS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GADD45GIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 78 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 78 nTPM
heart muscle: 72 nTPM
amygdala: 61 nTPM
cerebral cortex: 55 nTPM
hypothalamus: 54 nTPM
basal ganglia: 54 nTPM

Single-cell type

esophageal suprabasal cells: 582 nCPM
esophageal basal cells: 570 nCPM
migrating cytotrophoblasts: 417 nCPM
extravillous trophoblasts: 416 nCPM
cytotrophoblasts: 368 nCPM
gastric progenitor cells: 349 nCPM

Immune cell

memory B-cell: 103 nTPM
naive B-cell: 85 nTPM
naive CD4 T-cell: 55 nTPM
memory CD8 T-cell: 53 nTPM
memory CD4 T-cell: 51 nTPM
T-reg: 47 nTPM

Brain region

midbrain: 33 nTPM
medulla oblongata: 29 nTPM
cerebral cortex: 28 nTPM
hypothalamus: 28 nTPM
pons: 28 nTPM
thalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: -0.04
DepMap mean gene effect: -0.27
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial translation

Molecular functions

structural constituent of ribosome

Cellular components

Protein domainsUniProt · Pfam · InterPro

Large ribosomal subunit protein mL64
Large ribosomal subunit protein mL64 domain superfamily
Growth arrest and DNA-damage-inducible proteins-interacting protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GADD45GIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GADD45GIP1 as an antibody target. Whether an autoantibody or antibody against GADD45GIP1 could matter depends on whether native GADD45GIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GADD45GIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GADD45GIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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