Seroatlas · Human Serome Atlas

HIF1AN

Hypoxia-inducible factor 1-alpha inhibitor

Also known as: DKFZp762F1811, FIH1, FLJ20615, FLJ22027, HIF1N_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NWT6
Gene
HIF1AN
Ensembl
ENSG00000166135
Chromosome
10
Canonical length
349 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables several functions, including 2-oxoglutarate-dependent dioxygenase activity; NF-kappaB binding activity; and transition metal ion binding activity. Involved in negative regulation of Notch signaling pathway and positive regulation of myoblast differentiation. Located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

349 residues, UniProt reviewed canonical sequence.

>Q9NWT6|HIF1AN
     1  MAATAAEAVA SGSGEPREEA GALGPAWDES QLRSYSFPTR PIPRLSQSDP RAEELIENEE
    61  PVVLTDTNLV YPALKWDLEY LQENIGNGDF SVYSASTHKF LYYDEKKMAN FQNFKPRSNR
   121  EEMKFHEFVE KLQDIQQRGG EERLYLQQTL NDTVGRKIVM DFLGFNWNWI NKQQGKRGWG
   181  QLTSNLLLIG MEGNVTPAHY DEQQNFFAQI KGYKRCILFP PDQFECLYPY PVHHPCDRQS
   241  QVDFDNPDYE RFPNFQNVVG YETVVGPGDV LYIPMYWWHH IESLLNGGIT ITVNFWYKGA
   301  PTPKRIEYPL KAHQKVAIMR NIEKMLGEAL GNPQEVGPLL NTMIKGRYN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HIF1AN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 39 nTPM
  • tongue: 38 nTPM
  • testis: 13 nTPM
  • heart muscle: 12 nTPM
  • parathyroid gland: 11 nTPM
  • skin: 9.5 nTPM

Single-cell type

  • cardiomyocytes: 119 nCPM
  • late spermatids: 80 nCPM
  • late primary spermatocytes: 63 nCPM
  • early primary spermatocytes: 39 nCPM
  • retinal ganglion cells: 39 nCPM
  • neutrophil progenitors: 37 nCPM

Immune cell

  • eosinophil: 15 nTPM
  • basophil: 14 nTPM
  • non-classical monocyte: 13 nTPM
  • intermediate monocyte: 11 nTPM
  • T-reg: 9.8 nTPM
  • NK-cell: 9.1 nTPM

Brain region

  • midbrain: 18 nTPM
  • thalamus: 17 nTPM
  • amygdala: 16 nTPM
  • cerebral cortex: 16 nTPM
  • pons: 16 nTPM
  • hippocampal formation: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0.07
gnomAD missense Z
2.02
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HIF1AN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HIF1AN as an antibody target. Whether an autoantibody or antibody against HIF1AN could matter depends on whether native HIF1AN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HIF1AN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HIF1AN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HIF1AN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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