Seroatlas · Human Serome Atlas

ANKRD52

Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

Also known as: ANR52_HUMAN, FLJ34236, PP6-ARS-C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NB46
Gene: ANKRD52
Ensembl: ENSG00000139645
Chromosome: 12
Canonical length: 1076 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

No narrative summary is available for ANKRD52 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1076 residues, UniProt reviewed canonical sequence.

>Q8NB46|ANKRD52
     1  MGILSITDQP PLVQAIFSRD VEEVRSLLSQ KENINVLDQE RRTPLHAAAY VGDVPILQLL
    61  LMSGANVNAK DTLWLTPLHR AAASRNEKVL GLLLAHSADV NARDKLWQTP LHVAAANRAT
   121  KCAEALAPLL SSLNVADRSG RSALHHAVHS GHLETVNLLL NKGASLNVCD KKERQPLHWA
   181  AFLGHLEVLK LLVARGADLG CKDRKGYGLL HTAAASGQIE VVKYLLRMGA EIDEPNAFGN
   241  TALHIACYLG QDAVAIELVN AGANVNQPND KGFTPLHVAA VSTNGALCLE LLVNNGADVN
   301  YQSKEGKSPL HMAAIHGRFT RSQILIQNGS EIDCADKFGN TPLHVAARYG HELLISTLMT
   361  NGADTARRGI HDMFPLHLAV LFGFSDCCRK LLSSGQLYSI VSSLSNEHVL SAGFDINTPD
   421  NLGRTCLHAA ASGGNVECLN LLLSSGADLR RRDKFGRTPL HYAAANGSYQ CAVTLVTAGA
   481  GVNEADCKGC SPLHYAAASD TYRRAEPHTP SSHDAEEDEP LKESRRKEAF FCLEFLLDNG
   541  ADPSLRDRQG YTAVHYAAAY GNRQNLELLL EMSFNCLEDV ESTIPVSPLH LAAYNGHCEA
   601  LKTLAETLVN LDVRDHKGRT ALFLATERGS TECVEVLTAH GASALIKERK RKWTPLHAAA
   661  ASGHTDSLHL LIDSGERADI TDVMDAYGQT PLMLAIMNGH VDCVHLLLEK GSTADAADLR
   721  GRTALHRGAV TGCEDCLAAL LDHDAFVLCR DFKGRTPIHL ASACGHTAVL RTLLQAALST
   781  DPLDAGVDYS GYSPMHWASY TGHEDCLELL LEHSPFSYLE GNPFTPLHCA VINNQDSTTE
   841  MLLGALGAKI VNSRDAKGRT PLHAAAFADN VSGLRMLLQH QAEVNATDHT GRTALMTAAE
   901  NGQTAAVEFL LYRGKADLTV LDENKNTALH LACSKGHEKC ALMILAETQD LGLINATNSA
   961  LQMPLHIAAR NGLASVVQAL LSHGATVLAV DEEGHTPALA CAPNKDVADC LALILSTMKP
  1021  FPPKDAVSPF SFSLLKNCSI AAAKTVGGCG ALPHGASCPY SQERPGAIGL DGCYSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD52 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 23 nTPM
adrenal gland: 20 nTPM
cerebellum: 19 nTPM
parathyroid gland: 19 nTPM
tongue: 16 nTPM
pituitary gland: 13 nTPM

Single-cell type

adrenal cortex cells: 81 nCPM
myonuclei: 49 nCPM
adrenal medulla cells: 43 nCPM
retinal horizontal cells: 38 nCPM
cone photoreceptor cells: 37 nCPM
tuft cells: 35 nCPM

Immune cell

basophil: 0.4 nTPM
gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
total PBMC: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

pons: 60 nTPM
medulla oblongata: 52 nTPM
midbrain: 49 nTPM
thalamus: 46 nTPM
hypothalamus: 43 nTPM
cerebral cortex: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.09
gnomAD pLI: 1
gnomAD missense Z: 4.49
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANKRD52 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD52 as an antibody target. Whether an autoantibody or antibody against ANKRD52 could matter depends on whether native ANKRD52 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD52 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD52 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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