Seroatlas · Human Serome Atlas

ANKS3

Ankyrin repeat and SAM domain-containing protein 3

Also known as: ANKS3_HUMAN, FLJ32345, FLJ32767, KIAA1977

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZW76
Gene: ANKS3
Ensembl: ENSG00000168096
Chromosome: 16
Canonical length: 656 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homooligomer

OverviewNCBI Gene

Predicted to be located in cytoplasm. Predicted to be active in cilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

656 residues, UniProt reviewed canonical sequence.

>Q6ZW76|ANKS3
     1  MSELSDEASE PELLNRSLSM WHGLGTQVSG EELDVPLDLH TAASIGQYEV VKECVQRREL
    61  DLNKKNGGGW TPLMYASYIG HDTIVHLLLE AGVSVNVPTP EGQTPLMLAS SCGNESIAYF
   121  LLQQGAELEM KDIQGWTALF HCTSAGHQHM VRFLLDSGAN ANVREPICGF TPLMEAAAAG
   181  HEIIVQYFLN HGVKVDARDH SGATARMLAK QYGHMKIVAL MDTYSPSLPK SLYRSPEKYE
   241  DLSSSDESCP APQRQRPCRK KGVSIHEGPR ALARITGIGL GGRAPRPRYE QAPPRGYVTF
   301  NSSGENPLEE EGLCCRDVTS PINERDVESS SSSSSREEHA FCANLGPVQS SSSSEGLARA
   361  QGLSSEASVE SNEDSDHACK SSARKQAKSY MKTKNPDSQW PPRAATDREG FLAESSPQTQ
   421  RAPYSGPQDL AALLEQIGCL KYLQVFEEQD VDLRIFLTLT ESDLKEIGIT LFGPKRKMTS
   481  AIARWHSSAR PPGDALELAY ADRLEAEMQE LAIQLHKRCE EVEATRGQVC QEQELRAVVE
   541  SCLLEQDRAR EDLQARLRET WALARDAALV LDQLRACQAE LSSRVRQDQP PGAATLGLAV
   601  PPADSKGWQA SLQAMSLPEL SGALEDRVRE MGQALCLVTQ SLEKLQVLNG KKWRET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 10 nTPM
kidney: 8.4 nTPM
blood vessel: 8.1 nTPM
hypothalamus: 8.1 nTPM
cerebral cortex: 8 nTPM
colon: 7.9 nTPM

Single-cell type

rod photoreceptor cells: 78 nCPM
lactotrophs: 59 nCPM
gonadotrophs: 58 nCPM
somatotrophs: 56 nCPM
cone photoreceptor cells: 52 nCPM
corticotrophs: 52 nCPM

Immune cell

plasmacytoid DC: 2.2 nTPM
naive CD4 T-cell: 1.5 nTPM
naive B-cell: 1.3 nTPM
MAIT T-cell: 1.2 nTPM
memory B-cell: 1.2 nTPM
memory CD4 T-cell: 1.1 nTPM

Brain region

cerebellum: 6 nTPM
cerebral cortex: 5.5 nTPM
white matter: 5.4 nTPM
hypothalamus: 5.1 nTPM
pons: 5.1 nTPM
basal ganglia: 4.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ANKS3.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 200 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Short stature

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0
gnomAD missense Z: -1.76
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Sterile alpha motif domain
Ankyrin repeat
Sterile alpha motif/pointed domain superfamily
Ankyrin repeat-containing domain superfamily
SAM domain (Sterile alpha motif)
Ankyrin repeats (3 copies)
Ankyrin repeats (many copies)
Ankyrin repeat and SAM domain-containing protein 3, SAM domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANKS3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKS3 as an antibody target. Whether an autoantibody or antibody against ANKS3 could matter depends on whether native ANKS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKS3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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