Seroatlas · Human Serome Atlas

APBA3

Amyloid-beta A4 precursor protein-binding family A member 3

Also known as: APBA3_HUMAN, mint3, X11L2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O96018
Gene: APBA3
Ensembl: ENSG00000011132
Chromosome: 19
Canonical length: 575 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

575 residues, UniProt reviewed canonical sequence.

>O96018|APBA3
     1  MDFPTISRSP SGPPAMDLEG PRDILVPSED LTPDSQWDPM PGGPGSLSRM ELDESSLQEL
    61  VQQFEALPGD LVGPSPGGAP CPLHIATGHG LASQEIADAH GLLSAEAGRD DLLGLLHCEE
   121  CPPSQTGPEE PLEPAPRLLQ PPEDPDEDSD SPEWVEGASA EQEGSRSSSS SPEPWLETVP
   181  LVTPEEPPAG AQSPETLASY PAPQEVPGPC DHEDLLDGVI FGARYLGSTQ LVSERNPPTS
   241  TRMAQAREAM DRVKAPDGET QPMTEVDLFV STKRIKVLTA DSQEAMMDHA LHTISYTADI
   301  GCVLVLMARR RLARRPAPQD HGRRLYKMLC HVFYAEDAQL IAQAIGQAFA AAYSQFLRES
   361  GIDPSQVGVH PSPGACHLHN GDLDHFSNSD NCREVHLEKR RGEGLGVALV ESGWGSLLPT
   421  AVIANLLHGG PAERSGALSI GDRLTAINGT SLVGLPLAAC QAAVRETKSQ TSVTLSIVHC
   481  PPVTTAIIHR PHAREQLGFC VEDGIICSLL RGGIAERGGI RVGHRIIEIN GQSVVATPHA
   541  RIIELLTEAY GEVHIKTMPA ATYRLLTGQE QPVYL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APBA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 14 nTPM
spleen: 10 nTPM
liver: 9.7 nTPM
ovary: 8.7 nTPM
kidney: 7.9 nTPM
salivary gland: 7.9 nTPM

Single-cell type

enterocytes: 20 nCPM
syncytiotrophoblasts: 19 nCPM
esophageal apical cells: 17 nCPM
esophageal suprabasal cells: 16 nCPM
extravillous trophoblasts: 15 nCPM
decidual stromal cells: 14 nCPM

Immune cell

T-reg: 20 nTPM
gdT-cell: 13 nTPM
memory CD4 T-cell: 13 nTPM
memory CD8 T-cell: 13 nTPM
MAIT T-cell: 12 nTPM
naive B-cell: 12 nTPM

Brain region

white matter: 9.9 nTPM
medulla oblongata: 8 nTPM
basal ganglia: 7 nTPM
cerebral cortex: 7 nTPM
cerebellum: 6.6 nTPM
midbrain: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: -0.24
DepMap mean gene effect: 0.2
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of APBA3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APBA3 as an antibody target. Whether an autoantibody or antibody against APBA3 could matter depends on whether native APBA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APBA3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label APBA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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