RNASEL

Protein identityUniProt · HPA

UniProt accession

Q05823

Gene

RNASEL

Ensembl

ENSG00000135828

Chromosome

1

Canonical length

741 aa

Protein class

Enzymes, Human disease related genes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. The protein is involved in innate immunity and is active against multiple RNA viruses, including the influenza and SARS-CoV-2 viruses. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Nov 2021]

Canonical amino-acid sequenceUniProt

741 residues, UniProt reviewed canonical sequence.

>Q05823|RNASEL
     1  MESRDHNNPQ EGPTSSSGRR AAVEDNHLLI KAVQNEDVDL VQQLLEGGAN VNFQEEEGGW
    61  TPLHNAVQMS REDIVELLLR HGADPVLRKK NGATPFILAA IAGSVKLLKL FLSKGADVNE
   121  CDFYGFTAFM EAAVYGKVKA LKFLYKRGAN VNLRRKTKED QERLRKGGAT ALMDAAEKGH
   181  VEVLKILLDE MGADVNACDN MGRNALIHAL LSSDDSDVEA ITHLLLDHGA DVNVRGERGK
   241  TPLILAVEKK HLGLVQRLLE QEHIEINDTD SDGKTALLLA VELKLKKIAE LLCKRGASTD
   301  CGDLVMTARR NYDHSLVKVL LSHGAKEDFH PPAEDWKPQS SHWGAALKDL HRIYRPMIGK
   361  LKFFIDEKYK IADTSEGGIY LGFYEKQEVA VKTFCEGSPR AQREVSCLQS SRENSHLVTF
   421  YGSESHRGHL FVCVTLCEQT LEACLDVHRG EDVENEEDEF ARNVLSSIFK AVQELHLSCG
   481  YTHQDLQPQN ILIDSKKAAH LADFDKSIKW AGDPQEVKRD LEDLGRLVLY VVKKGSISFE
   541  DLKAQSNEEV VQLSPDEETK DLIHRLFHPG EHVRDCLSDL LGHPFFWTWE SRYRTLRNVG
   601  NESDIKTRKS ESEILRLLQP GPSEHSKSFD KWTTKINECV MKKMNKFYEK RGNFYQNTVG
   661  DLLKFIRNLG EHIDEEKHKK MKLKIGDPSL YFQKTFPDLV IYVYTKLQNT EYRKHFPQTH
   721  SPNKPQCDGA GGASGLASPG C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNASEL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

9.2 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RNASEL.

Disease | AllUniProt

Conditions RNASEL is implicated in, by any mechanism.

• Prostate cancer, hereditary, 1 (HPC1) MIM:601518

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 170 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Ovarian cancer
• Prostate cancer, hereditary, 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.13

gnomAD pLI

0

gnomAD missense Z

0.16

DepMap mean gene effect

-0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• defense response to virus
• fat cell differentiation
• mRNA processing
• negative regulation of viral genome replication
• positive regulation of D-glucose import
• positive regulation of transcription by RNA polymerase II
• protein phosphorylation
• regulation of mRNA stability
• RNA processing
• rRNA processing

Molecular functions

• ATP binding
• hydrolase activity
• identical protein binding
• protein kinase activity
• ribonucleoprotein complex binding
• RNA binding
• RNA endonuclease activity
• RNA nuclease activity
• rRNA binding
• zinc ion binding

Cellular components

• cytosol
• mitochondrial matrix
• nuclear matrix

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Ankyrin repeat
• KEN domain
• Protein kinase-like domain superfamily
• Ankyrin repeat-containing domain superfamily
• KEN domain superfamily
• Protein kinase domain
• Ribonuclease 2-5A
• Ankyrin repeats (3 copies)
• Ankyrin repeats (many copies)
• RNase L, RNase domain

KeywordsUniProt

• Acetylation
• ANK repeat
• Antiviral defense
• ATP-binding
• Cytoplasm
• Endonuclease
• Hydrolase
• Immunity
• Innate immunity
• Metal-binding
• Mitochondrion
• Nuclease
• Nucleotide-binding
• Repeat
• RNA-binding
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of RNASEL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ABCE1
• HIF1AN