Seroatlas · Human Serome Atlas

ANKRD49

Ankyrin repeat domain-containing protein 49

Also known as: ANR49_HUMAN, FGIF, FLJ20189, GBIF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WVL7
Gene: ANKRD49
Ensembl: ENSG00000168876
Chromosome: 11
Canonical length: 239 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Golgi apparatus

OverviewNCBI Gene

Involved in positive regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

239 residues, UniProt reviewed canonical sequence.

>Q8WVL7|ANKRD49
     1  MEKEKGNDDG IPDQENSLDF SEHFNQLELL ETHGHLIPTG TQSLWVGNSD EDEEQDDKNE
    61  EWYRLQEKKM EKDPSRLLLW AAEKNRLTTV RRLLSEKATH VNTRDEDEYT PLHRAAYSGH
   121  LDIVQELIAQ GADVHAVTVD GWTPLHSACK WNNTRVASFL LQHDADINAQ TKGLLTPLHL
   181  AAGNRDSKDT LELLLMNRYV KPGLKNNLEE TAFDIARRTS IYHYLFEIVE GCTNSSPQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD49 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 27 nTPM
tonsil: 22 nTPM
lymph node: 20 nTPM
thymus: 18 nTPM
epididymis: 17 nTPM
spleen: 16 nTPM

Single-cell type

somatotrophs: 50 nCPM
leydig cells: 46 nCPM
b-cells: 44 nCPM
enterocytes: 43 nCPM
t-cells: 43 nCPM
microglia: 42 nCPM

Immune cell

basophil: 86 nTPM
neutrophil: 48 nTPM
memory B-cell: 38 nTPM
naive B-cell: 36 nTPM
T-reg: 36 nTPM
eosinophil: 34 nTPM

Brain region

cerebellum: 16 nTPM
white matter: 14 nTPM
basal ganglia: 12 nTPM
thalamus: 12 nTPM
choroid plexus: 12 nTPM
pons: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: 0.89
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANKRD49 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD49 as an antibody target. Whether an autoantibody or antibody against ANKRD49 could matter depends on whether native ANKRD49 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD49 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD49 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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