Seroatlas · Human Serome Atlas

SUGT1

Protein SGT1 homolog

Also known as: SGT1, SGT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2Z0
Gene
SUGT1
Ensembl
ENSG00000165416
Chromosome
13
Canonical length
365 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nuclear bodies,Cytosol,Acrosome,Flagellar centriole,Mid piece,Principal piece,End piece

OverviewNCBI Gene

This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

365 residues, UniProt reviewed canonical sequence.

>Q9Y2Z0|SUGT1
     1  MAAAAAGTAT SQRFFQSFSD ALIDEDPQAA LEELTKALEQ KPDDAQYYCQ RAYCHILLGN
    61  YCVAVADAKK SLELNPNNST AMLRKGICEY HEKNYAAALE TFTEGQKLDI ETGFHRVGQA
   121  GLQLLTSSDP PALDSQSAGI TGADANFSVW IKRCQEAQNG SESEVWTHQS KIKYDWYQTE
   181  SQVVITLMIK NVQKNDVNVE FSEKELSALV KLPSGEDYNL KLELLHPIIP EQSTFKVLST
   241  KIEIKLKKPE AVRWEKLEGQ GDVPTPKQFV ADVKNLYPSS SPYTRNWDKL VGEIKEEEKN
   301  EKLEGDAALN RLFQQIYSDG SDEVKRAMNK SFMESGGTVL STNWSDVGKR KVEINPPDDM
   361  EWKKY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUGT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 37 nTPM
  • heart muscle: 35 nTPM
  • liver: 34 nTPM
  • testis: 32 nTPM
  • spinal cord: 32 nTPM
  • midbrain: 31 nTPM

Single-cell type

  • oocytes: 350 nCPM
  • late primary spermatocytes: 243 nCPM
  • extravillous trophoblasts: 196 nCPM
  • esophageal suprabasal cells: 175 nCPM
  • early spermatids: 175 nCPM
  • esophageal apical cells: 159 nCPM

Immune cell

  • basophil: 64 nTPM
  • eosinophil: 49 nTPM
  • T-reg: 46 nTPM
  • plasmacytoid DC: 41 nTPM
  • intermediate monocyte: 35 nTPM
  • non-classical monocyte: 34 nTPM

Brain region

  • white matter: 80 nTPM
  • cerebellum: 63 nTPM
  • basal ganglia: 61 nTPM
  • pons: 61 nTPM
  • hypothalamus: 59 nTPM
  • thalamus: 58 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.45
gnomAD missense Z
1
DepMap mean gene effect
-0.79
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SUGT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUGT1 as an antibody target. Whether an autoantibody or antibody against SUGT1 could matter depends on whether native SUGT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUGT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUGT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SUGT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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