Seroatlas · Human Serome Atlas

CSNK1A1

Casein kinase I isoform alpha

Also known as: CK1, CK1a, CK1alpha, CKIa, CKIalpha, KC1A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P48729
Gene
CSNK1A1
Ensembl
ENSG00000113712
Chromosome
5
Canonical length
337 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Enables protein serine/threonine kinase activity. Involved in several processes, including intermediate filament cytoskeleton organization; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of signal transduction. Located in cytoskeleton and nucleus. Part of beta-catenin destruction complex. Biomarker of Alzheimer's disease and inclusion body myositis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

337 residues, UniProt reviewed canonical sequence.

>P48729|CSNK1A1
     1  MASSSGSKAE FIVGGKYKLV RKIGSGSFGD IYLAINITNG EEVAVKLESQ KARHPQLLYE
    61  SKLYKILQGG VGIPHIRWYG QEKDYNVLVM DLLGPSLEDL FNFCSRRFTM KTVLMLADQM
   121  ISRIEYVHTK NFIHRDIKPD NFLMGIGRHC NKLFLIDFGL AKKYRDNRTR QHIPYREDKN
   181  LTGTARYASI NAHLGIEQSR RDDMESLGYV LMYFNRTSLP WQGLKAATKK QKYEKISEKK
   241  MSTPVEVLCK GFPAEFAMYL NYCRGLRFEE APDYMYLRQL FRILFRTLNH QYDYTFDWTM
   301  LKQKAAQQAA SSSGQGQQAQ TPTGKQTDKT KSNMKGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSNK1A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
199 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 199 nTPM
  • esophagus: 134 nTPM
  • skin: 115 nTPM
  • parathyroid gland: 93 nTPM
  • breast: 92 nTPM
  • urinary bladder: 89 nTPM

Single-cell type

  • suprabasal keratinocytes: 618 nCPM
  • neutrophils: 569 nCPM
  • basal keratinocytes: 539 nCPM
  • ocular epithelial cells: 485 nCPM
  • esophageal apical cells: 472 nCPM
  • pituicytes/fscs: 459 nCPM

Immune cell

  • basophil: 106 nTPM
  • total PBMC: 94 nTPM
  • myeloid DC: 80 nTPM
  • T-reg: 77 nTPM
  • classical monocyte: 72 nTPM
  • intermediate monocyte: 68 nTPM

Brain region

  • white matter: 148 nTPM
  • medulla oblongata: 146 nTPM
  • choroid plexus: 145 nTPM
  • thalamus: 139 nTPM
  • cerebellum: 138 nTPM
  • spinal cord: 138 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CSNK1A1.

Disease | ImmuneIEDB

Conditions an epitope on CSNK1A1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
1
gnomAD missense Z
4.3
DepMap mean gene effect
-0.9
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CSNK1A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSNK1A1 as an antibody target. Whether an autoantibody or antibody against CSNK1A1 could matter depends on whether native CSNK1A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSNK1A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CSNK1A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CSNK1A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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